{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:51Z","timestamp":1787015871738,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Burning mouth syndrome (BMS) is a chronic oral pain condition with unknown aetiology but assumed to involve peripheral\/central neuropathological and immune\u2010mediated inflammatory factors. We aimed at characterizing inflammatory and neurogenic profiles and oral symptomatology of patients with BMS based on response to a local anaesthetic lozenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with BMS were divided into an\n                      <jats:italic>Effect<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a013),\n                      <jats:italic>No effect<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a08) or\n                      <jats:italic>Unspecified<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02) group according to their response to a local anaesthetic lozenge on oral pain. Inflammation was assessed in blood plasma and saliva by analyses of IL\u20106, IL\u20108, IL\u201017A, IL\u201023 and TNF\u2010\u03b1 levels. The degree of inflammation and distribution of oestrogen receptor, NGF, NGF\u2010receptor, TRPV\u20101 and IL\u201017F in buccal mucosal tissue were investigated by immunohistochemistry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Immunoreactivity to the oestrogen receptor was most intense in the\n                      <jats:italic>Effect<\/jats:italic>\n                      group, whereas the\n                      <jats:italic>No effect<\/jats:italic>\n                      group tended to have higher plasma levels of the pro\u2010inflammatory cytokines.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings indicate that the response to treatment with local anaesthesia enables subgrouping of patients with BMS according to the potential pathogenic mechanisms. Effect of local anaesthesia indicates a peripheral neuropathology involving lack of oestrogen and upregulation of oestrogen receptors, and no effect indicates a systemic inflammation\u2010induced mechanism leading to increased levels of plasma cytokines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13267","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T00:53:21Z","timestamp":1577408001000},"page":"656-669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Characterization of burning mouth syndrome profiles based on response to a local anaesthetic lozenge"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5921-807X","authenticated-orcid":false,"given":"Charlotte","family":"Treldal","sequence":"first","affiliation":[{"name":"Clinical Research Centre Copenhagen University Hospital Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne","family":"Petersen","sequence":"additional","affiliation":[{"name":"Clinical Research Centre Copenhagen University Hospital Hvidovre Denmark"},{"name":"Section for Biostatistics Department of Public Health University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stine","family":"Mogensen","sequence":"additional","affiliation":[{"name":"Clinical Research Centre Copenhagen University Hospital Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Therkildsen","sequence":"additional","affiliation":[{"name":"Clinical Research Centre Copenhagen University Hospital Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jette","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Physiological Pharmaceutics Department of Pharmacy Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ove","family":"Andersen","sequence":"additional","affiliation":[{"name":"Clinical Research Centre Copenhagen University Hospital Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-5803","authenticated-orcid":false,"given":"Anne Marie Lynge","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Section for Oral Pathology and Oral Medicine Department of Odontology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.50764"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12666"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01209.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059498"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70134-5"},{"issue":"4","key":"e_1_2_8_7_1","first-page":"244","article-title":"Burning mouth and saliva","volume":"7","author":"Chimenos\u2010Kustner E.","year":"2002","journal-title":"Medicina Oral"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01100.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb10657.x"},{"issue":"2","key":"e_1_2_8_10_1","first-page":"117","article-title":"Pain and pain behavior in burning mouth syndrome: A pain diary study","volume":"26","author":"Forssell H.","year":"2012","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.11.016"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2003.12.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(87)90336-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i5.665"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.07.054"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2016.1269191"},{"key":"e_1_2_8_18_1","article-title":"Burning mouth syndrome and potential nociceptive structures in tongue biopsies","volume":"89","author":"J\u00f8rgensen M. 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