{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:53Z","timestamp":1787015933192,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE027070"],"award-info":[{"award-number":["DE027070"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE016353"],"award-info":[{"award-number":["DE016353"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01 BX000854"],"award-info":[{"award-number":["I01 BX000854"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mutation of the gene for acid sphingomyelinase (ASMase) causes Niemann\u2013Pick disease. However, the effect of ASMase deficiency on periodontal health is unknown. Periodontal disease is a disease resulting from infection and inflammation of periodontal tissue and alveolar bone that support the teeth. The goal of this study was to determine the role of ASMase deficiency in periodontal inflammation and alveolar bone loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We induced periodontitis in wild\u2010type and ASMase\u2010deficient (ASMase\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      ) mice with periodontal lipopolysaccharide (LPS) injection and compared the alveolar bone loss and periodontal inflammation between these mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Results showed that ASMase deficiency did not significantly change metabolic parameters, but exacerbated LPS\u2010induced alveolar bone loss, osteoclastogenesis, and periodontal tissue inflammation. To understand the mechanisms by which ASMase deficiency aggravates LPS\u2010induced periodontitis, we analyzed sphingolipids in periodontal tissues. Results showed that ASMase deficiency led to increases in not only sphingomyelin, but also ceramide (CER), a bioactive sphingolipid known to promote inflammation. Results further showed that ASMase deficiency increased CER de novo synthesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ASMase deficiency exacerbated LPS\u2010induced alveolar bone loss and periodontal inflammation. ASMase deficiency leads to an unexpected CER increase by stimulating de novo synthesis CER, which is likely to be involved in the ASMase deficiency\u2010exacerbated periodontitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13268","type":"journal-article","created":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T15:24:41Z","timestamp":1577546681000},"page":"637-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Acid sphingomyelinase deficiency exacerbates LPS\u2010induced experimental periodontitis"],"prefix":"10.1111","volume":"26","author":[{"given":"Yanchun","family":"Li","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Medical Genetics Department of Medicine College of Medicine Medical University of South Carolina Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyang","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Medical Genetics Department of Medicine College of Medicine Medical University of South Carolina Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Oral Biology School of Dental Medicine University at Buffalo Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith L.","family":"Kirkwood","sequence":"additional","affiliation":[{"name":"Departments of Oral Biology School of Dental Medicine University at Buffalo Buffalo New York"},{"name":"Department of Oral Oncology Roswell Park Comprehensive Cancer Center Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria F.","family":"Lopes\u2010Virella","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Medical Genetics Department of Medicine College of Medicine Medical University of South Carolina Charleston South Carolina"},{"name":"Ralph H. Johnson Veterans Affairs Medical Center Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2789-5580","authenticated-orcid":false,"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Medical Genetics Department of Medicine College of Medicine Medical University of South Carolina Charleston South Carolina"},{"name":"Ralph H. 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