{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:32:58Z","timestamp":1792830778111,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Oral leukoplakia has mixed and differing histopathological features, and it is thus difficult to reach an accurate histological diagnosis of oral leukoplakia based on a local biopsy alone. We recently demonstrated the significance of CD163<jats:sup>+<\/jats:sup> macrophages in oral carcinogenesis. Herein we sought to determine whether CD163<jats:sup>+<\/jats:sup> macrophages in biopsy specimens of oral leukoplakia help identify the overall histological nature of the lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Twenty\u2010six patients with tongue leukoplakia who underwent a histological examination by both a preoperative local biopsy and consecutive total excision were enrolled. We evaluated clinicopathological factors and the expression of CD163<jats:sup>+<\/jats:sup> macrophages based on a retrospective comparison of the histological diagnostic concordance between the biopsies and excisions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen patients (diagnostic\u2010agreement group) were diagnosed with squamous intraepithelial lesion based on both the biopsy and the excision. Nine patients (diagnostic\u2010discrepancy group) were diagnosed with invasive cancer by excision, although invasive cancer was not observed in their biopsy specimens. Compared to the diagnostic\u2010agreement group, the diagnostic\u2010discrepancy group had more tongue leukoplakia with non\u2010homogenous or high numbers of intraepithelial CD163<jats:sup>+<\/jats:sup> macrophages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The evaluation of intraepithelial CD163<jats:sup>+<\/jats:sup> macrophages in local biopsy specimens from tongue leukoplakia patients is a promising tool for cancer screening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13269","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T16:09:15Z","timestamp":1577722155000},"page":"527-536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Intraepithelial CD163<sup>+<\/sup> macrophages in tongue leukoplakia biopsy: A promising tool for cancer screening"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1130-7166","authenticated-orcid":false,"given":"Manabu","family":"Shigeoka","sequence":"first","affiliation":[{"name":"Division of Pathology Department of Pathology Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010ichiro","family":"Koma","sequence":"additional","affiliation":[{"name":"Division of Pathology Department of Pathology Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Kodama","sequence":"additional","affiliation":[{"name":"Division of Pathology Department of Pathology Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Nishio","sequence":"additional","affiliation":[{"name":"Division of Pathology Department of Pathology Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Akashi","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery Department of Surgery Related Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yokozaki","sequence":"additional","affiliation":[{"name":"Division of Pathology Department of Pathology Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12095"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp127"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.07.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01127.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80014-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/838632"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00513.x"},{"key":"e_1_2_8_10_1","volume-title":"General rules for clinical and pathological studies on oral cancer","author":"Japan Society of Oral Oncology","year":"2019"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0266-4356(87)90157-4"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-012-1202-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.01945.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12015"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000074646"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.5981\/jjhnc.37.7"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0915-6992(02)80003-6"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.290703.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2001.300207.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034773"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-685"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652410791316968"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07205"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132532"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.03.015"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-015-1735-6"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.12.6166"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1587-0"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2448"},{"key":"e_1_2_8_30_1","first-page":"112","volume-title":"WHO classification of head and neck tumors","author":"Naggar A. K.","year":"2017"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12125"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3892\/or_00000822"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-017-0623-6"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(03)00102-7"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1979.tb01824.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509182102"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(98)80007-9"},{"issue":"6","key":"e_1_2_8_38_1","first-page":"e11","article-title":"Oral squamous cell carcinoma: Early detection and improved 5\u2010year survival in 102 patients","volume":"66","author":"Sciubba J. J.","year":"2018","journal-title":"General Dentistry"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197509)36:3<1021::AID-CNCR2820360327>3.0.CO;2-W"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.228"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12188"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12657"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.1.287"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5715719"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12440"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.04.019"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28066"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197510)36:4<1386::AID-CNCR2820360430>3.0.CO;2-7"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoms.2015.02.007"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-019-01020-6"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.03.006"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12262"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2017.03.009"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12674"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020177"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.13269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.13269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.13269","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.13269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T06:40:19Z","timestamp":1694068819000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.13269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,13]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/odi.13269"],"URL":"https:\/\/doi.org\/10.1111\/odi.13269","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,13]]},"assertion":[{"value":"2019-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}