{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:10:10Z","timestamp":1792606210488,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81530033"],"award-info":[{"award-number":["81530033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500896"],"award-info":[{"award-number":["81500896"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700995"],"award-info":[{"award-number":["81700995"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The temporomandibular joint (TMJ) displays a high remodelling capability in response to occlusion changes. The purpose of the current study was to investigate the responses of TMJ condyles of growing mice to the installation of a unilateral anterior crossbite (UAC) prosthesis and the replacement of the UAC prothesis with a bilateral anterior elevation (BAE) prosthesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>C57BL\/6J mice were randomly assigned to the blank control and experimental groups. In mice in the experimental groups, UAC was created, while in others, BAE was created after the creation of UAC or removal of UAC. Changes in TMJ condylar cartilage and subchondral bone were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The degradation of condylar cartilage induced by UAC was reversed by BAE, as evaluated by cartilage histochemical changes, collagen II\u2010positive area, collagen X\u2010positive chondrocytes and expression levels of <jats:italic>Adamts\u20105<\/jats:italic>, <jats:italic>Mmp13<\/jats:italic>, <jats:italic>Tnf\u2010\u03b1<\/jats:italic> and <jats:italic>Il\u20101\u03b2<\/jats:italic>. Subchondral bone was assessed based on the subchondral bone volume, the number of TRAP\u2010positive cells and the <jats:italic>Opg\/Rankl<\/jats:italic> ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The growing mouse TMJ condyle displays a high remodelling capability, which can be degenerative or rehabilitative in response to the creation of UAC and the replacement of UAC with BAE. Early correction of occlusion is beneficial for the recovery of degenerative condyles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13274","type":"journal-article","created":{"date-parts":[[2020,1,4]],"date-time":"2020-01-04T10:04:56Z","timestamp":1578132296000},"page":"597-608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Effects of occlusion modification on the remodelling of degenerative mandibular condylar processes"],"prefix":"10.1111","volume":"26","author":[{"given":"Ping","family":"Zhou","sequence":"first","affiliation":[{"name":"Hunan Key Laboratory of Oral Health Research Hunan 3D Printing Engineering Research Center of Oral Care Hunan Clinical Research Center of Oral Major Diseases and Oral Health Xiangya Stomatological Hospital Xiangya School of Stomatology Central South University Changsha 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Oral Diseases School of Stomatology The Fourth Military Medical University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqin","family":"Lu","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Oral Health Research Hunan 3D Printing Engineering Research Center of Oral Care Hunan Clinical Research Center of Oral Major Diseases and Oral Health Xiangya Stomatological Hospital Xiangya School of Stomatology Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7373-385X","authenticated-orcid":false,"given":"Mei\u2010Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of Temporomandibular Joint Disorders and Oral and Maxillofacial Pain The Key Laboratory of Military Stomatology of State the National Clinical Research Center for Oral Diseases School of Stomatology The Fourth Military 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