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The mice subsequently underwent bilateral maxillary first molar extraction. After 8\u00a0weeks of modelling administration, the maxilla samples were examined by micro\u2010computed tomography and histological staining (haematoxylin and eosin, Masson's trichrome and tartrate\u2010resistant acid phosphatase) and the cytokine level was measured (enzyme\u2010linked immunosorbent assay and Western blot). To determine the role of TPTD in BRONJ, the same protocol as previously described was applied in 100 mice (80 received ZA\u00a0+\u00a0DEX, and 20 received saline). After 8\u00a0weeks of modelling administration, 80 ZA\u00a0+\u00a0DEX mice were randomly divided into four groups: three groups with subcutaneous administration of TPTD (i.e. T1\u20103, T2\u201010 and T3\u201030\u00a0\u00b5g\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup>) and one group with saline daily for the next 8\u00a0weeks. The other 20 saline mice continued to receive saline daily.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In Part 1, the level of receptor activator of nuclear factor\u2010kappa \u0392 ligand and the numbers of osteoclasts differed between the model and control groups. In Part 2, we found that TPTD had a positive effect on BRONJ in a mouse model based on clinical and histomorphological observations. Among the three treatment groups, the T1 and T2 groups significantly differed from the model group, whereas the T3 group showed no statistical differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Subcutaneous administration of TPTD has a beneficial effect on BRONJ in mice. Nevertheless, further studies are needed to determine whether the therapeutic effect on BRONJ is dose\u2010dependent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13275","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T07:17:15Z","timestamp":1578295035000},"page":"609-620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The effects of different doses of teriparatide on bisphosphonate\u2010related osteonecrosis of the jaw in mice"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8304-8605","authenticated-orcid":false,"given":"Wanlu","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Prosthodontics School &amp; Hospital of Stomatology Shanghai Engineering Research Center of Tooth Restoration and Regeneration Tongji University Shanghai 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