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The aim of this clinical trial was to evaluate two Se forms (<jats:italic>novel<\/jats:italic> topical hydrogel and oral capsules), solely, in treating erosive OLP based on clinical evaluation and salivary oxidative stress markers. Patients were allocated into one of three groups: group I, topical corticosteroids; group II, topical Se; and group III, systemic Se. Treatment lasted for 6\u00a0weeks; patients were clinically evaluated at baseline, 6, and 12\u00a0weeks. Biochemical analysis for salivary malondialdehyde (MDA) and total antioxidant capacity (TAC) levels at baseline and 6\u00a0weeks was performed. There was a significant reduction in signs and symptoms in response to all treatment modalities. However, there was no significant difference among the three groups at 6\u00a0weeks. At 12\u00a0weeks, group II had significantly lower pain scores compared with group I. Salivary MDA levels showed a significant decrease in patients of group I and group III. TAC levels showed no significant difference in response to treatment. Selenium can be proposed as a treatment for OLP. Salivary MDA levels can be a biomarker for OLP disease severity.<\/jats:p>","DOI":"10.1111\/odi.13285","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T06:40:11Z","timestamp":1579848011000},"page":"789-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Selenium: A sole treatment for erosive oral lichen planus (Randomized controlled clinical trial)"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7217-0012","authenticated-orcid":false,"given":"Passant O.","family":"Qataya","sequence":"first","affiliation":[{"name":"Faculty of Dentistry Oral Medicine, Periodontology, Diagnosis and Radiology Department Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naguiba Mahmoud","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Oral Medicine, Periodontology, Diagnosis and Radiology Department Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihal Mohamed","family":"Elguindy","sequence":"additional","affiliation":[{"name":"Faculty of Science Biochemistry Department Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"Ahmed Hafiz","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Industrial Pharmacy Department Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael Mahmoud","family":"Samy","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Industrial Pharmacy Department Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,10]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"86","article-title":"Comparative study of ketoconazole versus selenium sulphide shampoo in pityriasis versicolor","volume":"69","author":"Aggarwal K.","year":"2003","journal-title":"Indian Journal of Dermatology, Venereology, and Leprology"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojst.2011.12003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1667-2"},{"key":"e_1_2_8_5_1","first-page":"21","article-title":"Evaluation of plasma isoprostane in patients with oral lichen planus","volume":"17","author":"Amirchaghmaghi M.","year":"2016","journal-title":"Journal of Dentistry"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27230F"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2014.10.007"},{"key":"e_1_2_8_9_1","first-page":"716","article-title":"Development of satranidazole mucoadhesive gel for the treatment of periodontitis","volume":"10","author":"Bansal K.","year":"2009","journal-title":"An Official Journal of the American Association of Pharmaceutical Scientists"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-81-322-2032-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.169837"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels3010006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.06.022"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.05.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2018.01.021"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2017.11.002"},{"key":"e_1_2_8_17_1","article-title":"Getting started with PRIMER v7","volume":"20","author":"Clarke K. 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