{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:56:04Z","timestamp":1782536164890,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We reported the alveolar bone histology prior to dental extractions in cancer patients, who received bone\u2010targeting agents (BTA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Fifty\u2010four patients were included. Patients underwent extractions, and bone biopsies were taken.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Extractions were performed due to pain, swelling, purulence, fistula, and numbness, not responding to treatment, in 40 patients (group A); extractions due to asymptomatic, non\u2010restorable teeth, were performed in 14 patients (group B). Complete alveolar jaw bone histological necrosis was observed in 28 of 40 (70%) patients of group A and none of group B (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). The development of clinical osteonecrosis (MRON) was assessed in 44 patients; 10 patients, who were also treated with Low Level Laser Treatments\u2010LLLT, were excluded from this analysis, as the alternative therapies were a confounding factor. Twelve patients, with alveolar bone histological necrosis prior to extraction, developed medication\u2010related osteonecrosis of the jaw (MRONJ) compared with two patients with vital or mixed vital\/non\u2010vital bone (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0007). BTAs &gt;1\u00a0year and concurrent targeted therapy were also significantly associated with MRONJ (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.016 and <jats:italic>p<\/jats:italic>\u00a0=\u00a0.050).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pain, swelling, purulence, fistula, and numbness were significantly associated with complete bone histological necrosis prior to extractions and increased MRONJ development. Research is justified to explore whether histological necrosis represents an early stage of osteonecrosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13294","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T12:56:46Z","timestamp":1580734606000},"page":"955-966","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Alveolar bone histological necrosis observed prior to extractions in patients, who received bone\u2010targeting agents"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9036-6329","authenticated-orcid":false,"given":"Ourania","family":"Nicolatou\u2010Galitis","sequence":"first","affiliation":[{"name":"Clinic of Hospital Dentistry Densstal School National &amp; Kapodistrian University of Athens Athens 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