{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:33:49Z","timestamp":1789612429284,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81172564"],"award-info":[{"award-number":["81172564"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The study explored the potential function of astrocyte elevated gene\u20101 (AEG\u20101) on angiogenesis in tongue squamous cell carcinoma (TSCC) in TSCC cell lines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The different degrees of angiogenesis were detected in TSCC cell lines expressing different levels of AEG\u20101 by chick chorioallantoic membrane (CAM) experimental model. Next, we established xenografts of different TSCC cell lines with different expression levels of AEG\u20101 in nude mice and conducted immunohistochemistry to evaluate the expression of the angiogenesis\u2010associated factor, that is, vascular endothelial growth receptor factor 2 (VEGFR\u20102) and microvessel density (MVD). Vascular endothelial growth factor (VEGF) was detected by ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CAM assay showed that the number of vessels was significantly reduced in AEG\u20101\u2010down um1 cell line (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05), whereas the number was significantly increased in AEG\u20101\u2010over um2 cell line (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). Moreover, up\u2010regulated AEG\u20101 expression level was associated with higher tumor angiogenesis, which was reflected by augmented expression levels of VEGF (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01), VEGFR\u20102 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05), and MVD counting (\n                      <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>\n                      .01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrated that AEG\u20101 can promote tumor angiogenesis in TSCC and inhibition of tumor angiogenesis by repressing the expression of AEG\u20101 may be a novel potential treatment approach for TSCC.<\/jats:p>\n                  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