{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:50:03Z","timestamp":1747187403282,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81070843","81700991"],"award-info":[{"award-number":["81070843","81700991"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our aim was to verify the alleviation effect of sphingosine\u20101\u2010phosphate (S1P) in a miniature pig model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Thirty male miniature pigs were randomly separated into 10 groups in our experiment. We administered S1P through the parotid duct in a retrograde fashion 2\u00a0hr before irradiation (IR). The salivary flow rate and blood flow rate were tested 20\u00a0weeks after IR. The apoptotic level was checked at 12, 24\u00a0hr and 7\u00a0days post\u2010IR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty weeks after IR, the salivary flow rate of the IR\u2010side parotid gland in IR\u00a0+\u00a0S1P group can be maintained at about 40% of the non\u2010IR side, while only 20% was maintained in the IR group. The blood flow rate and microvascular density were significantly higher in the IR\u00a0+\u00a0S1P group than in the IR group. The apoptotic level and cleaved caspase\u20103 expression were downregulated in IR\u00a0+\u00a0S1P group, and the ratio of Bcl\u20102\/Bax was increased. The blood flow rate and CD31 level were significantly restored at 12, 24\u00a0hr and 7\u00a0days post\u2010IR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sphingosine\u20101\u2010phosphate may partially alleviate IR\u2010induced parotid dysfunction by decreasing apoptosis of microvascular endothelial cells and maintaining the blood flow rate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13302","type":"journal-article","created":{"date-parts":[[2020,2,8]],"date-time":"2020-02-08T08:05:07Z","timestamp":1581149107000},"page":"920-929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sphingosine\u20101\u2010phosphate alleviates irradiation\u2010induced parotid injury in a miniature pig model"],"prefix":"10.1111","volume":"26","author":[{"given":"Wen","family":"Pan","sequence":"first","affiliation":[{"name":"Outpatient Department of Oral and Maxillofacial Surgery School of Stomatology Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Hu","sequence":"additional","affiliation":[{"name":"Outpatient Department of Oral and Maxillofacial Surgery School of Stomatology Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Stomatology Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Outpatient Department of Oral and Maxillofacial Surgery School of Stomatology Capital Medical University Beijing China"},{"name":"Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Beijing Stomatological Hospital Capital Medical University Beijing 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