{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:17:12Z","timestamp":1777958232854,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The present study focused on investigating levels of oxidative stress, neutrophil elastase (NE), and insulin\u2010like growth factor\u2010binding protein 7 (IGFBP7) in oropharyngeal cancers (OC) with the presence and absence of periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A healthy non\u2010periodontitis group (H\u2010NP; <jats:italic>n<\/jats:italic>\u00a0=\u00a020), a systemically healthy chronic periodontitis group (H\u2010P; <jats:italic>n<\/jats:italic>\u00a0=\u00a020), a non\u2010periodontitis group with OC (OC\u2010NP; <jats:italic>n<\/jats:italic>\u00a0=\u00a012), and a chronic periodontitis group with OC (OC\u2010P; <jats:italic>n<\/jats:italic>\u00a0=\u00a016) formed the study groups. The levels of NE and IGFBP7 were measured in gingival crevicular fluid (GCF) and saliva. In addition, oxidative status was determined by evaluating total oxidant status (TOS), total antioxidant status (TAS), and OSI (TOS\/TAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gingival crevicular fluid NE was higher in all the groups compared with the H\u2010NP group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). Salivary NE was higher in the OC\u2010P and H\u2010P groups compared with the H\u2010NP and OC\u2010NP groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Salivary IGFBP7 was significantly higher in the OC\u2010NP and OC\u2010P groups compared with the H\u2010NP and H\u2010P groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). GCF TOS and OSI levels were significantly higher in all groups compared with the H\u2010NP group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gingival crevicular fluid NE levels were lower in healthy conditions compared with periodontal disease and OC. Salivary NE levels were higher in periodontal disease compared to states with no periodontal disease. Salivary IGFBP7 levels were higher in OC. Further analyses may help determine whether high salivary IGFBP7 levels distinguish OC from healthy conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13370","type":"journal-article","created":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T01:00:36Z","timestamp":1587776436000},"page":"1393-1401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Oxidative stress, neutrophil elastase and IGFBP7 levels in patients with oropharyngeal cancer and chronic periodontitis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7366-345X","authenticated-orcid":false,"given":"C\u00fcneyt As\u0131m","family":"Aral","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Inonu University Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sude Nur","family":"\u00d6l\u00e7er","sequence":"additional","affiliation":[{"name":"Private Practice Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4798-4548","authenticated-orcid":false,"given":"K\u00fcbra","family":"Aral","sequence":"additional","affiliation":[{"name":"Republic of Turkey Ministry of Health Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Kapila","sequence":"additional","affiliation":[{"name":"Department of Orofacial Sciences School of Dentistry University of California San Francisco San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01172.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/653537"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2017.06.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12047"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-010-9393-9"},{"key":"e_1_2_9_8_1","first-page":"3446","article-title":"Tissue and serum IGFBP7 protein as biomarker in high\u2010grade soft tissue sarcoma","volume":"5","author":"Benassi M. S.","year":"2015","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4209"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503163321104"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2005.03.009"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01732.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11627"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2005.00096.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01029.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00178.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2089-4"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2774"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2016.02.021"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.417"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-220"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.07.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.07.013"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3764-9"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21140"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.4248\/IJOS11075"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329811"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-3-27"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.11.5763"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201600754"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb18343.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9907-0"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.12.005"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v8.32762"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-016-0093-6"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2017.08.006"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2007.01.003"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M112.020933"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.06.058"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb01798.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.3.406"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.6"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0334"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.5.450"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2006.00952.x"},{"key":"e_1_2_9_47_1","first-page":"240","article-title":"New insights on oxidative stress in cancer","volume":"12","author":"Visconti R.","year":"2009","journal-title":"Current Opinion in Drug Discovery & Development"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-11-0240"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.06.002"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16550"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.13370","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.13370","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.13370","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.13370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T10:16:52Z","timestamp":1693909012000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.13370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,27]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/odi.13370"],"URL":"https:\/\/doi.org\/10.1111\/odi.13370","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,27]]},"assertion":[{"value":"2019-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}