{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:33:13Z","timestamp":1790357593127,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T00:00:00Z","timestamp":1590451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the responsiveness of measures of pain and oral health\u2010related quality of life (OH\u2010QoL) in patients with oral lichen planus (OLP) and to determine thresholds for minimal important change (MIC) and minimal important difference (MID) for use in this patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from baseline and 4\u2010month follow\u2010up including Visual Analog Scale (VAS), Numerical Rating Scale (NRS), 14\u2010item Oral Health Impact Profile (OHIP\u201014), 15\u2010item and 26\u2010item Chronic Oral Mucosal Disease Questionnaire (COMDQ\u201015; COMDQ\u201026) were collected from 157 patients with OLP. Responsiveness was assessed by testing hypotheses and calculating the area under the curve. MIC and MID were established based on triangulation of distribution\u2010based and anchor\u2010based estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results supported adequate responsiveness of VAS, NRS, COMDQ\u201015 and COMDQ\u201026 for use in OLP, while the OHIP\u201014 demonstrated relatively low sensitivity to detect improvement in the OLP status. Recommended meaningful improvement thresholds were as follows: VAS (MIC 16\u00a0mm; MID 18\u00a0mm), NRS (MIC\/MID 2 points), OHIP\u201014 (MIC\/MID 5 points), COMDQ\u201015 (MIC 5 points; MID 6 points) and COMDQ\u201026 (MIC\/MID 9 points).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides some evidence of responsiveness as well as establishing meaningful improvement thresholds in scores of pain and OH\u2010QoL measures in OLP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13379","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T08:00:46Z","timestamp":1588579246000},"page":"1464-1473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Meaningful improvement thresholds in measures of pain and quality of life in oral lichen planus"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2340-517X","authenticated-orcid":false,"given":"Paswach","family":"Wiriyakijja","sequence":"first","affiliation":[{"name":"UCL Eastman Dental Institute London UK"},{"name":"Department of Oral Medicine Faculty of Dentistry Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Porter","sequence":"additional","affiliation":[{"name":"UCL Eastman Dental Institute London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9006-9412","authenticated-orcid":false,"given":"Stefano","family":"Fedele","sequence":"additional","affiliation":[{"name":"UCL Eastman Dental Institute London UK"},{"name":"NIHR University College London Hospitals Biomedical Research Centre London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Hodgson","sequence":"additional","affiliation":[{"name":"Eastman Dental Hospital UCLH Foundation NHS Trust London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roddy","family":"McMillan","sequence":"additional","affiliation":[{"name":"Eastman Dental Hospital UCLH Foundation NHS Trust London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Shephard","sequence":"additional","affiliation":[{"name":"Eastman Dental Hospital UCLH Foundation NHS Trust London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richeal","family":"Ni Riordain","sequence":"additional","affiliation":[{"name":"UCL Eastman Dental Institute London UK"},{"name":"Department of Oral Medicine Cork University Dental School and Hospital Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,26]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Clinical Oral Medicine and Pathology","author":"Bruch J. 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