{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:48:33Z","timestamp":1781106513257,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to provide evidence on the impact of chronic periodontitis (CP) on the severity of erectile dysfunction (ED) through the assessment of the salivary level of tumor necrosis factor\u2010alpha (TNF\u2010\u03b1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>140 patients with chronic periodontitis and erectile dysfunction were enrolled in this study and then randomly allocated to the control group (70 participants received delayed periodontal treatment) or test group (70 participants were subjected to immediate periodontal therapy). The assessment of the clinical and serological outcomes was done at baseline and 3\u00a0months postoperatively. This included pocket depth (PD), visible plaque, clinical attachment level (CAL), bleeding on probing (BOP), level of tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), and the severity of erectile dysfunction. Periodontal therapy consists of oral hygiene instructions and single\u2010visit scaling and root planing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences regarding the serological and clinical outcomes at baseline between the two groups (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05). At 3\u2010month follow\u2010up, the PD, BOP, CAL, and visible dental plaque means in the control group were significantly higher than those in the test group (PD: 4.94\u00a0\u00b1\u00a00.647\u00a0mm vs. 4.25\u00a0\u00b1\u00a00.619\u00a0mm; BOP: 49.03\u00a0\u00b1\u00a029.98 vs. 6.20\u00a0\u00b1\u00a07.14; CAL: 4.96\u00a0\u00b1\u00a00.631\u00a0mm vs. 4.31\u00a0\u00b1\u00a00.591\u00a0mm; visible dental plaque: 48.49\u00a0\u00b1\u00a030.07 vs. 5.83\u00a0\u00b1\u00a06.51) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.00). Compared with baseline findings, both groups showed significant reductions in TNF\u2010\u03b1 in serum, salivary TNF\u2010\u03b1, and severity of erectile dysfunction (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The non\u2010surgical periodontal therapy could significantly improve the severity of erectile dysfunction in addition to periodontal and serological parameters. Salivary TNF\u2010\u03b1 could be used as a new diagnostic tool to detect the severity of erectile dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13380","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T05:31:24Z","timestamp":1588656684000},"page":"1548-1557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Salivary tumor necrosis factor\u2010alpha to detect the severity of erectile dysfunction: A randomized clinical trial"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7886-5205","authenticated-orcid":false,"given":"Yasser","family":"El\u2010Makaky","sequence":"first","affiliation":[{"name":"Faculty of Dentistry Tanta University Tanta Egypt"},{"name":"College of Dentistry Taibah University Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soha","family":"Abdalla Hawwam","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer","family":"Hifnawy","sequence":"additional","affiliation":[{"name":"College of Dentistry Taibah University Saudi Arabia"},{"name":"Faculty of Medicine Beni\u2010Suef University Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00142.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2006.12.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.00971.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.06.068"},{"key":"e_1_2_9_7_1","first-page":"5","article-title":"chronic periodontitis as risk indicator of erectile dysfunction in young population: C\u2010adro\u20105060","volume":"23","author":"Chou M.\u2010H.","year":"2016","journal-title":"International Journal of Urology"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01498.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080132"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12039"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.05.004"},{"issue":"3","key":"e_1_2_9_12_1","first-page":"305","article-title":"Management of erectile dysfunction","volume":"81","author":"Heidelbaugh J. 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