{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T14:41:21Z","timestamp":1767192081719},"reference-count":27,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T00:00:00Z","timestamp":1598745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Significant pain from HIV\u2010associated sensory neuropathy (HIV\u2010SN) affects 40% of HIV\u2010infected individuals treated with antiretroviral therapy (ART). The most salient symptom of the neuropathy is pain, which frequently is moderate\u2010to\u2010severe intensity, associated with reduced activities and physical function, sleep disruption, increased severity of depression, and anxiety. Yet, evidence for managing painful HIV\u2010SN is poor. The purpose of this study was to verify by scientific evidence the neuropathy complication in HIV\/AIDS patients to develop effective pain management strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Design: Systematic review. Data sources: PubMed (MEDLINE), Cochrane, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.controlled-trials.com\">www.controlled-trials.com<\/jats:ext-link>. Selection criteria: the filter \u201cEnglish\u201d was used, timeframed searched was 2009\u20132019, randomized controlled trials (RCT). Keywords were verified in MeSH \u201cPeripheral Nervous System Disease\u201d and \u201cAntiretroviral Agents\u201d or \u201cAntiretroviral therapy.\u201d Review method: the PRISMA flowchart was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>A systematic search following PRISMA guidelines was carried out, and 12 specific articles\/studies on the subject were selected. The results revealed that HIV therapy, aging, body mass index, height, and systemic conditions influence neuropathy conditions in HIV\/AIDS patients. The multistudies focused on pain management approaches such as administration of pain medication, drug combination to prevent side effects, or ART with minimal side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sensory neuropathy is a frequent complication of HIV infection and ART. An understanding of the mechanism and pathophysiology of neuropathy in HIV is urgently required to develop alternative treatment modalities and to evaluate preventive strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13398","type":"journal-article","created":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T20:46:57Z","timestamp":1598820417000},"page":"149-152","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Neuropathy complication of antiretroviral therapy in HIV\/AIDS patients"],"prefix":"10.1111","volume":"26","author":[{"given":"Saka","family":"Winias","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Faculty of Dental Medicine Universitas Airlangga Surabaya Indonesia <!--Query ID=\"q2\" Text=\"AUTHOR: Please check that authors and their affiliation are correct.\"-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desiana","family":"Radithia","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Faculty of Dental Medicine Universitas Airlangga Surabaya Indonesia <!--Query ID=\"q2\" Text=\"AUTHOR: Please check that authors and their affiliation are correct.\"-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diah","family":"Savitri Ernawati","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Faculty of Dental Medicine Universitas Airlangga Surabaya Indonesia <!--Query ID=\"q2\" Text=\"AUTHOR: Please check that authors and their affiliation are correct.\"-->"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,30]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"HIV in the cART era and the mitochondrial: immune interface in the CNS","author":"Adam J.","year":"2019"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1258\/td.2008.080213"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126297"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.121912"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.120"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328345889d"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-012-0119-9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4065\/81.2.213"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000205"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12084"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.16.1.18867"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2012.00373.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-015-0327-1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-014-0235-9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar\/ilt047"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v19i2.20"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2497"},{"issue":"12","key":"e_1_2_7_20_1","first-page":"e14433","article-title":"Pharmacological treatment of painful HIV\u2010associated sensory neuropathy: A systematic review and meta\u2010 analysis of randomised controlled","volume":"5","author":"Phillips T. 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