{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:29:50Z","timestamp":1790951390711,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T00:00:00Z","timestamp":1598745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present here the first reported case of a non\u2010syndromic cleft lip and palate (NSCLP) in an HIV\u2010exposed newborn of a mother on antiretroviral therapy (ART) in Indonesia. Genetic testing was performed to confirm a suspected genetic condition. Genomic DNA was extracted from the blood, and genetic variations of <jats:italic>the interferon regulatory factor<\/jats:italic> 6 (<jats:italic>IRF<\/jats:italic>6) rs642961 (Mspl) (G&gt;A) and <jats:italic>transforming growth factor alpha<\/jats:italic> (<jats:italic>TGFA<\/jats:italic>) <jats:italic>Bam<\/jats:italic>HI (rs11466297, A&gt;C) and <jats:italic>Rsa<\/jats:italic>I (rs3732248, C&gt;T) were performed by PCR\u2010RFLP and <jats:italic>IRF<\/jats:italic>6 gene analysis by PCR sequencing. Genotyping of DNA sequence variants in the <jats:italic>IRF<\/jats:italic>6 gene showed both parents had genotype GA, while the child had genotype GG (genotype wild type). There was no difference observed in the <jats:italic>TGFA Bam<\/jats:italic>HI gene variant between the child and her mother and father that were wild\u2010type polymorphisms (normal), while the <jats:italic>Rsa<\/jats:italic>1 polymorphisms of them were heterozygotes. A genetic variant of <jats:italic>IRF<\/jats:italic>6 might be a protective factor for NSCLP, while <jats:italic>Rsa<\/jats:italic>1 gene variant (A) allele can be considered to be the risk factor associated with NSCLP development. This case report also highlights the possible etiologic role of ART in NSCLP; therefore, early control of adverse effects of ART might be an important factor in decreasing the incidence of the congenital anomalies in HIV\u2010infected children.<\/jats:p>","DOI":"10.1111\/odi.13403","type":"journal-article","created":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T20:46:57Z","timestamp":1598820417000},"page":"165-168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic variation of <i>IRF<\/i>6 and <i>TGFA<\/i> genes in an HIV\u2010exposed newborn with non\u2010syndromic cleft lip palate"],"prefix":"10.1111","volume":"26","author":[{"given":"Irna","family":"Sufiawati","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Faculty of Dentistry Universitas Padjadjaran Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ani Melani","family":"Maskoen","sequence":"additional","affiliation":[{"name":"Department of Oral Biology Faculty of Dentistry Universitas Padjadjaran Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eky Setiawan Soeria","family":"Soemantri","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Faculty of Dentistry Universitas Padjadjaran Bandung Indonesia <!--Query ID=\"q5\" Text=\"AUTHOR: Please check that authors and their affiliations are correct.\"-->"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.9503.1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181e74a2f"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1597\/10-095"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.137932"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2933"},{"issue":"4","key":"e_1_2_5_7_1","first-page":"168","article-title":"Association of transforming growth factor alpha polymorphisms with nonsyndromic cleft lip and palate in Iranian population","volume":"7","author":"Ebadifar A.","year":"2015","journal-title":"Avicenna Journal of Medical Biotechnology"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ors.12117"},{"issue":"1","key":"e_1_2_5_9_1","first-page":"163","article-title":"Risk factors involved in orofacial cleft predisposition \u2010 Review","volume":"10","author":"Kawalec A.","year":"2015","journal-title":"Open Medicine (Warsaw, Poland)"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31381"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045441"},{"issue":"1","key":"e_1_2_5_12_1","first-page":"1","article-title":"Studies of the candidate genes TGFB2, MSX1, TGFA, and TGFB3 in the etiology of cleft lip and palate in the Philippines","volume":"34","author":"Lidral A. 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