{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T04:31:35Z","timestamp":1749184295601,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We assessed the periodontal situation radiologically according to tumour p16 status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Patients with a diagnosis of tonsillar cancer and availability of a digital panoramic radiograph (DPR) during a 5\u2010year period were included in this retrospective study. The predictor variables were periodontal stability, marginal bone loss, marginal bone loss without periodontal stability and total number of teeth. Periodontal status was compared with p16 status, age, gender, smoking and alcohol use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 115 patients included in the analyses (p16\u2010negative, <jats:italic>n<\/jats:italic>\u00a0=\u00a024; p16\u2010positive, <jats:italic>n<\/jats:italic>\u00a0=\u00a091), smoking (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001), heavy alcohol use (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001) and total number of teeth (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0001) were significantly associated with p16 status. Current smoking (OR\u00a0=\u00a07.3) and heavy alcohol use (OR\u00a0=\u00a010.1) increased the risk of p16\u2010negative cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with p16\u2010negative tonsillar carcinoma had less teeth than patients with p16\u2010positive tumours. Other periodontal findings were common in both groups without statistical significance. Heavy alcohol use and smoking were the most important risk factors for p16\u2010negative tonsillar carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13437","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T20:35:20Z","timestamp":1590438920000},"page":"1625-1630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Periodontitis in tonsil cancer patients\u2014A comparative study in accordance with tumour p16 status"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7446-6474","authenticated-orcid":false,"given":"Arvi","family":"Kein\u00e4nen","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Marinescu\u2010Gava","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Helsinki Helsinki Finland"},{"name":"HUS Radiology (Medical Imaging Center) Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Uittamo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaana","family":"Hagstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Helsinki and Helsinki University Hospital Helsinki Finland"},{"name":"Research Programs Unit Translational Cancer Biology University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia","family":"Marttila","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Sn\u00e4ll","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs112"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2017.1405279"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-018-9475-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195683"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065497"},{"volume-title":"WHO classification of head and neck tumours","year":"2017","author":"El\u2010Naggar A. 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