{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:45:03Z","timestamp":1793151903220,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify factors which influence the intraoral prevalence of human herpes viruses (HHVs) using mucosal swabs, saliva samples and qPCR analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>In this cross\u2010sectional observational study, matched saliva and oral swabs were collected from a total of 115 subjects: 70 immunocompetent subjects with no mucosal abnormalities, 22 with mucosal abnormalities and 23 therapeutically immunocompromised individuals. Extracted DNA was analysed by multiplex qPCR for detection and quantification of HHVs 1\u20136.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At least one human herpes virus was detected in 77.1% of immunocompetent individuals with no mucosal abnormalities, with EBV the most commonly detected at 61.4%. HHV\u20106 was detected in 17.1%, HSV\u20101 in 4.3% and CMV in 1.1%. Detection was higher in saliva than in oral swabs. There was no detection of HSV\u20102 or VZV. Neither presence of oral mucosal abnormality nor therapeutic immunocompromise was related to increased detection of human herpes virus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Commensal detection rates of EBV are high, and caution in clinical correlation of positive detection is warranted. Commensal CMV rates are low, and detection is likely to be clinically relevant. This study presents a comprehensive commensal detection rate of HHVs 1\u20136 by qPCR in saliva and swabs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13523","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T16:52:52Z","timestamp":1593622372000},"page":"378-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Intraoral human herpes viruses detectable by PCR in majority of patients"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8412-1114","authenticated-orcid":false,"given":"Tami","family":"Yap","sequence":"first","affiliation":[{"name":"Melbourne Dental School University of Melbourne  Melbourne Vic. Australia"},{"name":"Department of Dermatology Royal Melbourne Hospital  Melbourne Vic. Australia"},{"name":"Faculty of Medicine Dentistry and Health Science University of Melbourne  Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuan","family":"Khor","sequence":"additional","affiliation":[{"name":"Melbourne Dental School University of Melbourne  Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Seo","family":"Kim","sequence":"additional","affiliation":[{"name":"Melbourne Dental School University of Melbourne  Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Melbourne Dental School University of Melbourne  Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny Sung","family":"Won Yun","sequence":"additional","affiliation":[{"name":"Department of Dermatology Royal Melbourne Hospital  Melbourne Vic. Australia"},{"name":"Faculty of Medicine Dentistry and Health Science University of Melbourne  Melbourne Vic. 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