{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T17:21:05Z","timestamp":1778347265990,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T00:00:00Z","timestamp":1595635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the effects of hyaluronic acid (HA) as an adjunct to temporomandibular joint (TMJ) arthroscopy, relative to standard TMJ arthroscopy, in Wilkes stage\u2010III and stage\u2010IV patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A randomized clinical trial design was utilized (ClinicalTrials.gov NCT04110587). 51 patients were allocated to a TMJ arthroscopy (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a025) or a TMJ arthroscopy plus HA (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a026) group. Visual analog scale joint pain scores, maximum mouth opening (MMO), and muscle pain were measured at baseline, and at 3, 6, 9, and 12\u00a0months. Disk position on magnetic resonance imaging was evaluated at baseline and 12\u00a0months. Oral health\u2010related quality of life (OHRQoL) was assessed at baseline, and at 6 and 12\u00a0months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No group differences were observed in clinical or radiographic measurements (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2265\u00a0.05). The results do not indicate any benefit of HA as an adjuvant therapy to arthroscopy during follow\u2010up months 3\u201312. TMJ arthroscopy improved OHRQoL at 6 and 12\u00a0months (Oral Health Impact Profile\u201014 questionnaire scores of \u221214.59 and \u221214.27, 95% confidence intervals\u00a0=\u00a0\u221217.55 to \u221211.63 and \u221217.27 to \u221211.27) respectively, as well as pain and MMO, at all follow\u2010up time points (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A beneficial effect of HA injection during TMJ arthroscopy after the 3\u2010month follow\u2010up was not observed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13524","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T13:53:53Z","timestamp":1593611633000},"page":"301-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["TMJ arthroscopy with hyaluronic acid: A 12\u2010month randomized clinical trial"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2547-2296","authenticated-orcid":false,"given":"Oscar Gabriel","family":"Casta\u00f1o\u2010Joaqui","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Bucofacial Prosthesis Complutense University of Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Cano\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties Complutense University of Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juli\u00e1n","family":"Campo\u2010Trapero","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties Complutense University of Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Fernando","family":"Mu\u00f1oz\u2010Guerra","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital of La Princesa  Madrid Spain"},{"name":"Autonomous University of Madrid  Madrid Spain"},{"name":"Department of Oral and Maxillofacial Surgery University Hospital Montepr\u00edncipe San Pablo CEU University  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2019.10.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2001.23368"},{"issue":"1","key":"e_1_2_8_4_1","first-page":"3","article-title":"Quality of life in patients with temporomandibular disorders. 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