{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:09:26Z","timestamp":1792069766839,"version":"4.4.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RI2813\/2\u20101"],"award-info":[{"award-number":["RI2813\/2\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare success rates between the sub\u2010periosteal prepared (SPP) muco\u2010periosteal flap and the epi\u2010periosteal prepared (EPP) mucosa flap and the feasibility of alveoplasty after surgical tooth extractions in patients undergoing\/after antiresorptive treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Patients with an indication for preventive tooth extraction undergoing\/after antiresorptive treatment were enrolled over a 24\u2010month period in a parallel\u2010group randomized clinical pilot trial and randomly assigned for primary wound closure to either the SPP or the EPP group. The primary outcome was treatment failure 8\u00a0weeks after surgery. To assess the feasibility of alveoplasty, necrotic bone changes at the time point of tooth extraction were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and sixty patients were randomized to the SSP (<jats:italic>n<\/jats:italic>\u00a0=\u00a082) or the EPP (<jats:italic>n<\/jats:italic>\u00a0=\u00a078) group. One hundred and fifty\u2010seven patients met the primary endpoint 8\u00a0weeks after surgery with five treatment failures for the SPP group (6.3%) and 18 (23.4%) for the EPP group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.004). A significant relationship (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001) was observed between symptomatic teeth and non\u2010vital bone found in 54.8% of all biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The strong superiority of the muco\u2010periosteal flap as primary wound closure revealed the feasibility and effectiveness of the study. The large number of necrotic biopsies emphasizes the importance of alveoplasty as a preventive measure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13556","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T20:39:47Z","timestamp":1595018387000},"page":"532-546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Wound closure and alveoplasty after preventive tooth extractions in patients with antiresorptive intake\u2014A randomized pilot trial"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3911-262X","authenticated-orcid":false,"given":"Oliver","family":"Ristow","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Heidelberg Heidelberg 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