{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:07:27Z","timestamp":1781579247405,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Non\u2010syndromic cleft lip with or without palate is one of the most common birth malformations.\n                      <jats:italic>TP63<\/jats:italic>\n                      and\n                      <jats:italic>GREM1<\/jats:italic>\n                      were recently reported to be associated with NSCL\/P. However, there were few studies focused on their associations in non\u2010syndromic cleft lip only (NSCLO).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Initial screening and replication in large cohorts were used to locate the susceptible SNPs of\n                      <jats:italic>TP63<\/jats:italic>\n                      and\n                      <jats:italic>GREM1<\/jats:italic>\n                      . Firstly, variations were screened among 192 NSCLO cases by the Sanger sequencing. Then, we selected five associated SNPs in initial screening phase and replicated among 1,006 NSCLO cases and 1,823 normal controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Initial chi\u2010square test showed that rs7653848, rs7624324, rs6790167, and rs1345186 in\n                      <jats:italic>TP63<\/jats:italic>\n                      and rs2280738 in\n                      <jats:italic>GREM1<\/jats:italic>\n                      achieved statistical significance (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05); the subsequent replication analysis showed that rs1345186 was specifically significant in right\u2010side cleft lip (RCL;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.017, OR\u00a0=\u00a01.33, and 95% CI: 1.05\u20131.69).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study firstly used the subphenotype of cleft lip samples to verify the association between\n                      <jats:italic>TP63<\/jats:italic>\n                      and\n                      <jats:italic>GREM1<\/jats:italic>\n                      , which indicated that\n                      <jats:italic>TP63<\/jats:italic>\n                      is a promising susceptible gene for RCL in Chinese population. And further confirmed the different etiology in the right\u2010sided cleft lip, left\u2010sided cleft lip, and bilateral cleft lip of NSCLO. This will give new reference for the future research and genetic counseling.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13566","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T15:35:08Z","timestamp":1595259308000},"page":"559-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["SNPs at TP63 gene was specifically associated with right\u2010side cleft lip in Han Chinese population"],"prefix":"10.1111","volume":"27","author":[{"given":"Bin","family":"Yin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases &amp; Department of Cleft Lip and Palate West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Yu","family":"Shi","sequence":"additional","affiliation":[{"name":"Division of Growth and Development and Section of Orthodontics School of Dentistry University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Song","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases &amp; Department of Cleft Lip and Palate West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases &amp; Department of Cleft Lip and Palate West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0129-0367","authenticated-orcid":false,"given":"Zhong\u2010Lin","family":"Jia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases &amp; Department of Cleft Lip and Palate West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1396"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.580"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.333"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2933"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31541"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24238"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201100199"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12212"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(15)30337-6"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.06.020"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.069385"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008357"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.089615"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2263"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34011"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.036442"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-016-1754-7"},{"issue":"13","key":"e_1_2_11_19_1","first-page":"2862","article-title":"A multi\u2010ethnic genome\u2010wide association study identifies novel loci for non\u2010syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13","volume":"25","author":"Leslie E. 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