{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T20:37:48Z","timestamp":1773952668781,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Aims of this study were to test the efficacy of anti\u2010BP180\u2010NC160 ELISA in the diagnosis of oral pemphigoid compared to the gold standard, represented by direct immunofluorescence and pathological examination, to correlate the antibody titers with the severity of the disease and the demographical data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Patients with a suspect of oral pemphigoid were enrolled and underwent biopsy and sera collection both, in order to perform histopathological examination, direct immunofluorescence and ELISA. The test outcomes were compared, and ELISA sensitivity, specificity, accuracy, and negative and positive predictive values were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ELISA showed good specificity (83.3%), while sensitivity was only 50%. A moderate correlation between antibody titers and disease severity was recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mucomembranous Pemphigoid is an autoimmune autoantibody\u2010mediated blistering disease, often affecting exclusively the oral mucosa. Currently, the biopsy is required to diagnose this disease, but serological tests are also commonly employed during clinical practice as adjunctive tools. BP180\u2010NC160 ELISA should be considered an ancillary diagnostic test in course of oral pemphigoid; direct immunofluorescence\u00a0+\u00a0histologic examination remains the diagnostic gold standard.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13574","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T15:09:50Z","timestamp":1596035390000},"page":"525-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of BP180\u2010NC16A ELISA in exclusive oral pemphigoid diagnosis. A comparative study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9030-3739","authenticated-orcid":false,"given":"Massimo","family":"Petruzzi","sequence":"first","affiliation":[{"name":"Interdisciplinary Department of Medicine University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9067-8808","authenticated-orcid":false,"given":"Marilina","family":"Tampoia","sequence":"additional","affiliation":[{"name":"Interdisciplinary Department of Medicine University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2143-3799","authenticated-orcid":false,"given":"Rosario","family":"Serpico","sequence":"additional","affiliation":[{"name":"Multidisciplinary Department of Medical\u2010Surgical and Odontostomatological Specialties University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3550-1812","authenticated-orcid":false,"given":"Dorina","family":"Lauritano","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery Centre of Neuroscience Milan University of Milan\u2010Bicocca Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Lajolo","sequence":"additional","affiliation":[{"name":"Head and Neck Department School of Dentistry Fondazione Policlinico Universitario A. Gemelli \u2010 IRCCS\" Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2677-0869","authenticated-orcid":false,"given":"Alberta","family":"Lucchese","sequence":"additional","affiliation":[{"name":"Multidisciplinary Department of Medical\u2010Surgical and Odontostomatological Specialties University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6467-2039","authenticated-orcid":false,"given":"Fedora","family":"Della Vella","sequence":"additional","affiliation":[{"name":"Interdisciplinary Department of Medicine University of Bari \u201cAldo Moro\u201d Bari 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