{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:50:39Z","timestamp":1747187439950,"version":"3.40.5"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This review examined the comparative efficacy and safety of antifungal agents in preventing oral candidiasis among patients on cancer treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic review and network meta\u2010analysis based on randomised controlled trials that compared antifungal agents to placebo or other antifungal agents used in patients undergoing cancer treatment. Relative ranking of antifungal agents was evaluated with surface under the cumulative ranking (SUCRA) probability score. A total of 20 randomised controlled trials (3,215 participants) comparing 11 interventions were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with placebo, clotrimazole was ranked the best agent for preventing the incidence of oral candidiasis (risk ratio (RR), 0.21 [95% CI 0.08 to 0.55]; SUCRA\u00a0=\u00a00.89). Fluconazole was ranked the safest among other antifungal agents (SUCRA\u00a0=\u00a00.80), whereas clotrimazole (SUCRA\u00a0=\u00a00.36) and amphotericin B (SUCRA\u00a0=\u00a00.18) were ranked low for safety. Amphotericin B was associated with highest risk of adverse events (RR, 3.52 [95% CI 1.27 to 9.75]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clotrimazole is the most effective in preventing oral candidiasis, whereas fluconazole has the most favourable risk\u2010benefit profile in patients undergoing cancer treatment. However, we are unable to recommend clotrimazole as the best choice to prevent oral candidiasis due to unavailability of studies comparing clotrimazole with other antifungal agents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13588","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T01:39:20Z","timestamp":1596764360000},"page":"1631-1643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Antifungal agents in preventing oral candidiasis in clinical oncology: A network meta\u2010analysis"],"prefix":"10.1111","volume":"27","author":[{"given":"Yee","family":"Shen Loo","sequence":"first","affiliation":[{"name":"School of Pharmacy International University Medical Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tse","family":"Yee Wong","sequence":"additional","affiliation":[{"name":"School of Pharmacy International University Medical Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajesh K.","family":"Veettil","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice School of Pharmacy International Medical University Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Se Wong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice School of Pharmacy International Medical University Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4279-7420","authenticated-orcid":false,"given":"Divya","family":"Gopinath","sequence":"additional","affiliation":[{"name":"Oral Diagnostics and Surgical Sciences School of Dentistry International Medical University Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siew","family":"Mooi Ching","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-8721","authenticated-orcid":false,"given":"Rohit","family":"Kunnath Menon","sequence":"additional","affiliation":[{"name":"Division of Clinical Dentistry School of Dentistry International Medical University Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.78.922.455"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(80)90147-8"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S118892"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2016.11.004"},{"issue":"3","key":"e_1_2_12_6_1","first-page":"24","article-title":"Prophylaxis of candidiasis in cancer patients","volume":"17","author":"Bodey G. 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