{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:44:28Z","timestamp":1781091868617,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to evaluate the levels of serum and gingival crevicular fluid (GCF)\u00a0human beta\u2010defensin\u20102 (hBD\u20102), an antimicrobial peptide that takes roles in inflammatory diseases, in patients with chronic periodontitis (CP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A total of one hundred and one individuals, 59 controls and 42 patients with CP, participated in this study. Clinical index measurements were recorded during the periodontal examination, and radiographic evaluation was also performed. The serum and gingival crevicular fluid (GCF) samples were taken from all of the participants, and the hBD\u20102 levels were determined biochemically by\u00a0enzyme\u2010linked immunosorbent assay (ELISA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our study, hBD\u20102 GCF levels in CP (stages II\u2010IV periodontitis based on the new 2018 classification of periodontal diseases) group (2.77\u00a0ng\/30\u00a0s) were higher than in the\u00a0periodontally\u00a0healthy (2.51\u00a0ng\/30\u00a0s; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.047) individuals. In contrast, serum hBD\u20102 levels in CP (2.92\u00a0ng\/ml) were lower compared with those in healthy controls (7.75\u00a0ng\/ml, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Interestingly, our results showed that while higher hBD\u20102 GCF levels are associated with CP, lower serum hBD\u20102 levels were detected in CP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13597","type":"journal-article","created":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T18:39:45Z","timestamp":1596998385000},"page":"993-1000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of gingival crevicular fluid and serum human beta\u2010defensin\u20102 levels between periodontal health and disease"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4260-5978","authenticated-orcid":false,"given":"Ayla","family":"\u00d6zt\u00fcrk","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Dentistry Ondokuz May\u0131s University Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevda","family":"Kurt\u2010Bayrakdar","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry Ondokuz May\u0131s University Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahattin","family":"Avci","sequence":"additional","affiliation":[{"name":"Department of Biochemistry School of Medicine Ondokuz May\u0131s University Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"issue":"4","key":"e_1_2_7_2_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2002.003421.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01347.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0904-2512.2004.00143.x"},{"issue":"2","key":"e_1_2_7_6_1","first-page":"119","article-title":"Antimicrobial peptides in the oral environment: Expression and function in health and disease","volume":"7","author":"Dale B. 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