{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:05:31Z","timestamp":1793829931124,"version":"4.6.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate whether salivary lactate dehydrogenase (LDH) levels are increased in patients with oral cancer (OC) or oral potentially malignant disorders (OPMD) when compared to a healthy control group (CG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We conducted a comprehensive search of specialized databases (PubMed\/MEDLINE, The Cochrane Library, Web of Science, Scopus, and OpenGrey), including observational analytical studies evaluating the salivary LDH levels (in UI\/L or \u03bc\/L) in OC or OPMD patients and compared them with a CG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen case\u2013control studies were included. A total of 755 patients were evaluated, including 303 OC cases, 149 OPMD cases, and 303 controls. The meta\u2010analysis showed that LDH levels were higher within the OC group than the CG (SMD 9.49; 95% CI 6.97\u201312; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.00001). Patients with oral leucoplakia (SMD 11.67; 95% CI 1.01\u201322.33; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03) and oral submucous fibrosis (SMD 25.83; 95% CI \u22121.74\u201353.40; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.07) also presented higher levels than the CG. In addition, OC patients had higher salivary LDH levels than oral leucoplakia patients (SMD 5.62; 95% CI 2.14\u20139.11; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002). Heterogeneity was high across all the evaluated studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The determination of salivary LDH may be a useful method for screening and tracking OC and OPMD, but new protocolized studies are required to establish precise cutoff values.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13630","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T14:23:03Z","timestamp":1599142983000},"page":"44-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Salivary LDH in oral cancer and potentially malignant disorders: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1330-4885","authenticated-orcid":false,"given":"\u00d3scar","family":"Iglesias\u2010Vel\u00e1zquez","sequence":"first","affiliation":[{"name":"Department of Dental Clinical Specialties ORALMED Research Group School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5727-0920","authenticated-orcid":false,"given":"Rosa Mar\u00eda","family":"L\u00f3pez\u2010Pintor","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties ORALMED Research Group School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Gonz\u00e1lez\u2010Serrano","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties ORALMED Research Group School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Casa\u00f1as","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties ORALMED Research Group School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties ORALMED Research Group School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties ORALMED Research Group School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01172.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.18295\/squmj.2018.18.03.009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2007.04.008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJPM.IJPM_140_16"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22386"},{"issue":"4","key":"e_1_2_9_7_1","first-page":"40","article-title":"Salivary lactate dehydrogenase enzyme activity in oral submucous fibrosis: A biochemical and clinicopathological study","volume":"2","author":"Bhambal A. 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