{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:44Z","timestamp":1772160824399,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671007"],"award-info":[{"award-number":["81671007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this study, we sought to determine the expression profiles of long non\u2010coding RNAs (lncRNAs) and messenger RNAs (mRNAs) and construct functional networks to analyze their potential roles following botulinum toxin type A (BTXA)\u2010mediated inhibition of salivary secretion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The submandibular gland of rats in the BTXA and control groups was injected with BTXA and saline, respectively. Microarray analysis was used to identify the differentially expressed lncRNAs and mRNAs. Gene ontology and pathway analysis were performed to examine the biological functions. Functional networks, including lncRNA\u2010mRNA co\u2010expression and competing endogenous RNA (ceRNA) networks, were constructed to reveal the interaction between the coding and non\u2010coding genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Microarray analysis revealed that 254 lncRNAs and 631 mRNAs were differentially expressed between the BTXA and control groups. Bioinformatic analysis revealed that most of the mRNAs were closely related to transmembrane transporter activity. lncRNA\u2010mRNA co\u2010expression and ceRNA networks were constructed, and several critical mRNA\u2010lncRNA axes and key microRNAs related to salivary secretion were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study identified differentially expressed lncRNAs and mRNAs through microarray analysis and explored the interactions between the coding and non\u2010coding genes through bioinformatic analysis. These findings provide new insights into the mechanism of BTXA\u2010mediated inhibition of salivary secretion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13633","type":"journal-article","created":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T05:45:32Z","timestamp":1599371132000},"page":"1171-1183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Aberrantly expressed lncRNAs and mRNAs after botulinum toxin type A inhibiting salivary secretion"],"prefix":"10.1111","volume":"27","author":[{"given":"Qian\u2010Ying","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Peking University School of Basic Medical Sciences Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5935-1911","authenticated-orcid":false,"given":"Ruo\u2010Lan","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Peking University School of Basic Medical Sciences Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Gang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP271143"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb18338.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-017-0104-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.08.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20171142"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)61435-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-005-0100-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(95)00132-8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200614"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608384104"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.19-27062"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008760200"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2957941"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.002378"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20067"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12201"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.164863"},{"key":"e_1_2_8_19_1","first-page":"241","volume-title":"Calcium entry channels in non\u2010excitable cells","author":"Peng J. 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