{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:45:05Z","timestamp":1767339905496,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify the immunohistochemical pattern of non\u2010tumoral epithelium adjacent to lip cancer (ANTE) to unveil molecular alterations and potential biomarkers in lip cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A systematic search at MEDLINE, EMBASE and proceedings Web of Science, OpenGrey and WorldCat. The PICOS outline (Population: lip cancer patients; Intervention: immunostaining with biomarkers in surgical specimens; Comparisons: ANTE versus LC; Outcomes: primary\u2014to identify the immunohistochemical pattern of peritumoral epithelium and secondary\u2014to assess the immunoreactivity of LC epithelium; and Study design: cross\u2010sectional, case\u2010control and cohort studies).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 339 records were identified. Seven studies reporting on ANTE and LCs were included in the qualitative synthesis, and 4 of them (p53 immunostaining) were selected for meta\u2010analysis. In the ANTE group, the pooled prevalence of p53 was 0.74 (95% CI: 0.66 \u2013 0.82), while in the lip squamous cell carcinoma group this prevalence was\u00a00.83 (95% CI: 0.75 \u2013 0.89).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Similar immunoexpression was found in lip epithelium adjacent to lip carcinoma, even in epithelia with normal appearance or mild histological alterations. The role of biomarkers in the follow\u2010up of actinic cheilitis patients deserves additional clinical assessment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13643","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T09:36:26Z","timestamp":1600421786000},"page":"57-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Immunohistochemical analysis of epithelium adjacent to lip cancer: A meta\u2010analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7911-5190","authenticated-orcid":false,"given":"Pablo","family":"Varela\u2010Centelles","sequence":"first","affiliation":[{"name":"CS Praza do Ferrol EOXI Lugo Cervo e Monforte Galician Health Service Lugo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0791-6639","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Gonzalez\u2010Moles","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Granada Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Seoane\u2010Romero","sequence":"additional","affiliation":[{"name":"University General Hospital Ciudad Real Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yago","family":"Leira\u2010Feijoo","sequence":"additional","affiliation":[{"name":"Health Research Institute of Santiago de Compostela (IDIS) Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahi","family":"Takkouche","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine School of Medicine and Dentistry University of Santiago de Compostela Santiago de Compostela (A Coru\u00f1a) Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Manuel","family":"Seoane\u2010Romero","sequence":"additional","affiliation":[{"name":"Department of Surgery and Medical\u2010Surgical Specialties School of Medicine and Health Sciences University of Oviedo Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,5]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1016\/S1808-8694(15)31043-0"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1136\/jech-2013-203104"},{"key":"e_1_2_8_4_1","first-page":"2421","article-title":"p53 protein expression in squamocellular carcinomas of the lip","volume":"13","author":"Berner A.","year":"1993","journal-title":"Anticancer Research"},{"key":"e_1_2_8_5_1","first-page":"136","article-title":"Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion","volume":"1","author":"Brash D. 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