{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:39:03Z","timestamp":1788565143201,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:00:00Z","timestamp":1602288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The objective was to explore the effectiveness of photobiomodulation therapy for treating patients who suffer xerostomia and\/or hyposalivation due to the most prevalent clinical diagnoses. We searched PubMed, Scopus, Web of Science, CINAHL and Cochrane Library for randomized or clinical controlled trials published until 31 October 2019. Risk of bias assessment and meta\u2010analysis were conducted using the Cochrane tools. A total of 274 records were retrieved, and 11 met the inclusion criteria. Interventions whose parameters ranged between wavelengths of 790\u2013830\u00a0nm (infrared), 30\u2013120\u00a0mW of power and an energy density below 30\u00a0J\/cm\u20102 were associated with improvements in xerostomia\/hyposalivation. As for the assessment of methodological quality, 10 of the 11 articles included had a high risk of overall bias. Only 3 articles provided sufficient information to conduct a meta\u2010analysis for quality of life, compared with placebo in patients with burning mouth syndrome, showing a standardized mean difference between groups from baseline of \u22120.90 (\u22121.48; \u22120.32). The present review and meta\u2010analysis suggest that photobiomodulation therapy is an effective, non\u2010invasive and safe approach in patients with xerostomia. However, despite the potential, it is not possible to reach a reliable consensus on the parameters to be used, and future studies should be conducted by standardizing intervention protocols.<\/jats:p>","DOI":"10.1111\/odi.13648","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T21:16:53Z","timestamp":1600809413000},"page":"1115-1126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Acute and cumulative benefits of Photobiomodulation for xerostomia: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6825-4213","authenticated-orcid":false,"given":"Noelia","family":"Galiano\u2010Castillo","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, Faculty of Health Sciences University of Granada Granada Spain"},{"name":"Sport and Health Joint University Institute (iMUDS) Granada Spain"},{"name":"Biohealth Research Institute in Granada (ibs.GRANADA) Granada Spain"},{"name":"'Cu\u00eddate' Support Unit for Oncology Patients (UAPO\u2010Cu\u00eddate) Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8255-7544","authenticated-orcid":false,"given":"Lizhou","family":"Liu","sequence":"additional","affiliation":[{"name":"Centre for Health, Activity, and Rehabilitation Research, School of Physiotherapy University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5854-3567","authenticated-orcid":false,"given":"Mario","family":"Lozano\u2010Lozano","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Faculty of Health Sciences University of Granada Granada Spain"},{"name":"Sport and Health Joint University Institute (iMUDS) Granada Spain"},{"name":"Biohealth Research Institute in Granada (ibs.GRANADA) Granada Spain"},{"name":"'Cu\u00eddate' Support Unit for Oncology Patients (UAPO\u2010Cu\u00eddate) Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2456-7055","authenticated-orcid":false,"given":"Steve","family":"Tumilty","sequence":"additional","affiliation":[{"name":"Centre for Health, Activity, and Rehabilitation Research, School of Physiotherapy University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3834-1711","authenticated-orcid":false,"given":"Irene","family":"Cantarero\u2010Villanueva","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Faculty of Health Sciences University of Granada Granada Spain"},{"name":"Sport and Health Joint University Institute (iMUDS) Granada Spain"},{"name":"Biohealth Research Institute in Granada (ibs.GRANADA) Granada Spain"},{"name":"'Cu\u00eddate' Support Unit for Oncology Patients (UAPO\u2010Cu\u00eddate) Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2968-6950","authenticated-orcid":false,"given":"George David","family":"Baxter","sequence":"additional","affiliation":[{"name":"Centre for Health, Activity, and Rehabilitation Research, School of Physiotherapy University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12952"},{"key":"e_1_2_8_3_1","volume-title":"Xerostomia (Dry Mouth)","author":"American Dental Association","year":"2019"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.10.022"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.52298"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-1897-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2124-x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.09.036"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2472-2"},{"issue":"6","key":"e_1_2_8_10_1","first-page":"e787","article-title":"Efficacy of the photobiomodulation therapy in the treatment of the burning mouth syndrome","volume":"24","author":"Bardellini E.","year":"2019","journal-title":"Medicina Oral Patologia Oral Y Cirugia Bucal"},{"key":"e_1_2_8_11_1","first-page":"189","volume-title":"Electrotherapy: Evidence\u2010Based Practice","author":"Baxter G. 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