{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:51Z","timestamp":1772160831784,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Periodontal disease and diabetes mellitus (DM) are highly prevalent and interrelated diseases, resulting in altered host response microbiota. Thus, this study aimed to evaluate the impact of DM on local levels of lipopolysaccharide (LPS) and lipoteichoic acid (LTA) and their relationship with cytokines and matrix metalloproteinases\u2019 (MMPs) profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This case\u2013control study included diabetic (n\u00a0=\u00a015) and non\u2010diabetic (n\u00a0=\u00a015) subjects presenting Stage 3\u20104, Grade C, Periodontitis. Gingival crevicular fluid (GCF) was collected, and LPS and LTA levels were analyzed by enzyme\u2010linked immunosorbent assay (ELISA), while IFN\u2010\u03b3, IL\u201010, IL\u201017, IL\u20101\u03b2, IL\u20104, MMP\u20102, and MMP\u20109 were measured by LUMINEX\/MAGpix. Mann\u2013Whitney and Spearman\u2019s correlation tests were used to compared and to correlate variables (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher levels of LTA, LPS, IL\u201010, IL\u20101\u03b2, and MMP\u20102 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) and lower levels of IL\u201017 were found in the DM group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Non\u2010diabetic subjects presented higher LPS, IFN\u2010\u03b3, IL\u201017, and MMP\u20102 levels and lower IL\u201010 concentration (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). No significant correlation was seen between LPS and cytokine profile in non\u2010diabetic. Local levels of LTA were positively correlated with IL\u201017 and MMP\u20102 and negatively with IL\u201010.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LTA and LPS drove the inflammatory profile through the modulation of cytokines and MMPs in a different manner in DM and non\u2010diabetic subjects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13661","type":"journal-article","created":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T15:05:20Z","timestamp":1601823920000},"page":"1325-1333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Subgingival endotoxin and lipoteichoic acid modulate cytokine production in diabetic subjects: A Case\u2013control Study"],"prefix":"10.1111","volume":"27","author":[{"given":"Thiago P.","family":"Rangel","sequence":"first","affiliation":[{"name":"Department of Prosthodontics and Periodontics Dental School of Piracicaba Campinas State University  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelio A.","family":"Reis","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics Dental School of Piracicaba Campinas State University  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Caponi","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics Dental School of Piracicaba Campinas State University  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa C. S.","family":"Pena","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics Dental School of Piracicaba Campinas State University  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina G. S.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics Dental School of Piracicaba Campinas State University  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9468-0729","authenticated-orcid":false,"given":"Mauro P.","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Division of Periodontology FOSJC College of Dentistry S\u00e3o Paulo State University  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2518-0135","authenticated-orcid":false,"given":"Ingrid F.","family":"Mathias\u2010Santamaria","sequence":"additional","affiliation":[{"name":"Division of Periodontology FOSJC College of Dentistry S\u00e3o Paulo State University  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9234-0536","authenticated-orcid":false,"given":"Marcio Z.","family":"Casati","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics Dental School of Piracicaba Campinas State University  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1743-5855","authenticated-orcid":false,"given":"Renato C. 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