{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:20:14Z","timestamp":1776126014498,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the efficacy of photobiomodulation to that of topical clobetasol 0.05% in patients with symptomatic oral lichen planus (OLP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010four patients with symptomatic OLP were randomly allocated into two groups: (a) the Control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a017), application of topical clobetasol propionate 0.05% three times a day for 30 consecutive days with laser placebo applied twice a week to mask the treatment, and (b) the photobiomodulation group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a017), laser application twice a week, totalling 8 sessions, and gel placebo for 30 consecutive days to mask the treatment. Evaluations were performed once a week during treatment and 30, 60 and 90\u00a0days after treatment. The following parameters were evaluated: pain, clinical scores, clinical resolution and recurrence rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Photobiomodulation and propionate clobetasol 0.05% were able to significantly decrease pain in oral lichen planus patients and improve clinical scores during treatment and follow\u2010up. Both the Control and photobiomodulation groups presented similar clinical resolution and recurrence rates. Most importantly, no difference was observed between treatments during treatment and follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings indicate that photobiomodulation twice a week is as effective as corticoid therapy in treating oral lichen planus. Moreover, photobiomodulation is a safe and non\u2010invasive therapy with the remarkable advantage of no adverse effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13662","type":"journal-article","created":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T15:20:43Z","timestamp":1601824843000},"page":"1205-1216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Photobiomodulation is effective in oral lichen planus: A randomized, controlled, double\u2010blind study"],"prefix":"10.1111","volume":"27","author":[{"given":"Elza P.","family":"Ferri","sequence":"first","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences Nove de Julho University UNINOVE S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen R. L.","family":"Cunha","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences Nove de Julho University UNINOVE S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clery S.","family":"Abboud","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences Nove de Julho University UNINOVE S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8141-6029","authenticated-orcid":false,"given":"Camila","family":"de Barros Gallo","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio","family":"de Sousa Sobral","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences Nove de Julho University UNINOVE S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7228-6146","authenticated-orcid":false,"given":"Daniela","family":"de Fatima Teixeira da Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences Nove de Julho University UNINOVE S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-9064","authenticated-orcid":false,"given":"Anna Carolina R. T.","family":"Horliana","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences Nove de Julho University UNINOVE S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7854-2833","authenticated-orcid":false,"given":"Adriana L.\u2010d.\u2010S.","family":"Franco","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences Nove de Julho University UNINOVE S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3067-9224","authenticated-orcid":false,"given":"Maria Fernanda Set\u00fabal D.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences Nove de Julho University UNINOVE S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12619"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2233-7"},{"key":"e_1_2_9_4_1","first-page":"66","article-title":"Oral lichen planus. A review","volume":"74","author":"Anuradha C. H.","year":"2008","journal-title":"The New York State Dental Journal"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12821"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1999.tb00063.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1999.tb01988.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12260"},{"issue":"10","key":"e_1_2_9_9_1","first-page":"519","article-title":"Oral lichen planus: A review","volume":"58","author":"Carrozzo M.","year":"2009","journal-title":"Minerva Stomatologica"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.06.022"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/625048","article-title":"Effects of low\u2010level laser therapy on M1\u2010related cytokine expression in monocytes via histone modification","volume":"2014","author":"Chen C.\u2010H.","year":"2014","journal-title":"Mediators Inflammation"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.05.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06920.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01191.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58548-9"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-014-0068-6"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.19.6.068002"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01142.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2015.072"},{"issue":"10","key":"e_1_2_9_20_1","first-page":"e024083","article-title":"Efficacy of photobiomodulation on oral lichen planus: A protocol study for a double\u2010blind, randomized controlled clinical trial","volume":"8","author":"Ferri E. P.","year":"2018","journal-title":"British Medical Journal Open"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.2013.10"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1109\/JSTQE.2016.2561201"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-05041-3"},{"key":"e_1_2_9_24_1","first-page":"59","article-title":"Lichen planus \u2013 an update","volume":"4","author":"Gupta S. B.","year":"2013","journal-title":"International Journal of Pharmaceutical and Biomedical Science"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12634"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2017.4401"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15771"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01221.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2010.2876"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2015.27.5.485"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.03.011"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28592"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13188"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705384"},{"key":"e_1_2_9_35_1","first-page":"CD001168","article-title":"Interventions for treating oral lichen planus: Corticosteroid therapies","volume":"2","author":"Lodi G.","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2018.02.001"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.02.023"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2019.12.019"},{"key":"e_1_2_9_39_1","article-title":"The effect of diode laser and topical steroid on serum level of TNF\u2010alpha in oral lichen planus patients","volume":"8","author":"Othman N. A.","year":"2016","journal-title":"Journal of Clinical and Experimental Dentistry"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.07.028"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.04.004"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.07.013"},{"key":"e_1_2_9_43_1","article-title":"A retrospective study of 171 patients with oral lichen planus in the East Bohemia \u2010 Czech Republic \u2010 single center experience","volume":"6","author":"Radochov\u00e1 V.","year":"2014","journal-title":"Journal of Clinical and Experimental Dentistry"},{"key":"e_1_2_9_44_1","first-page":"156","article-title":"Oral lichen planus and lichenoid lesions: What's new?","volume":"51","author":"Schmidt\u2010Westhausen A. M.","year":"2020","journal-title":"Quintessence International"},{"issue":"1","key":"e_1_2_9_45_1","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.4103\/0975-7406.191976","article-title":"A randomized triple\u2010blind clinical trial to compare the effectiveness of topical triamcinolone acetonate (0.1%), clobetasol propionate (0.05%), and tacrolimus orabase (0.03%) in the management of oral lichen planus","volume":"8","author":"Sivaraman S.","year":"2016","journal-title":"Journal of Pharmacy and Bioallied Sciences"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1992.tb00974.x"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00125.x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-019-0869-z"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.13662","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.13662","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.13662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T13:35:22Z","timestamp":1693402522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.13662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,26]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/odi.13662"],"URL":"https:\/\/doi.org\/10.1111\/odi.13662","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ODI.13662\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.13662\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.13662\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.13662\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.13662\/v2\/response1","asserted-by":"object"}]},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,26]]},"assertion":[{"value":"2020-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}