{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:36:31Z","timestamp":1791822991595,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of the study was to evaluate the effect of non\u2010surgical periodontal treatment on gingival crevicular fluid (GCF) periostin levels in patients with gingivitis (G) and periodontitis (P).<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and methods<\/jats:title><jats:p>A total of 90 subjects, 30 patients with P, 30 with G, and 30 periodontally healthy (H) subjects were included. Patients with periodontal disease received non\u2010surgical periodontal treatment. GCF periostin levels were assessed at baseline, at the 6th week, and the 3rd month after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>It was found that GCF periostin level was the lowest in the H group (89.31[47.12] pg\/30\u00a0sec), followed by the G group (132.82[145.14] pg\/30\u00a0sec), and the highest in the P group (207.75[189.45] pg\/30\u00a0sec). These differences were statistically significant between H and the other groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). After treatment, GCF periostin levels significantly decreased at the 6th week and the 3rd month in the G group, at the 3rd month in the P group compared to baseline values (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study suggest that GCF periostin plays a role as a reliable biological marker in the pathogenesis of periodontal disease and non\u2010surgical periodontal treatment is effective in decreasing GCF periostin levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13664","type":"journal-article","created":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T19:30:15Z","timestamp":1601839815000},"page":"1478-1486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The effect of non\u2010surgical periodontal treatment on gingival crevicular fluid periostin levels in patients with gingivitis and periodontitis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0962-2039","authenticated-orcid":false,"given":"Rana","family":"Arslan","sequence":"first","affiliation":[{"name":"Oral and Dental Health Center Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1518-4159","authenticated-orcid":false,"given":"Meltem","family":"Karsiyaka Hendek","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Kirikkale University Kirikkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8131-6810","authenticated-orcid":false,"given":"Ucler","family":"Kisa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine Kirikkale University Kirikkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7298-8589","authenticated-orcid":false,"given":"Ebru","family":"Olgun","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Kirikkale University Kirikkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"149","article-title":"Periodontal indexes for and in practice","volume":"80","author":"Ainamo J.","year":"1976","journal-title":"Tandlaegebladet"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.170315"},{"key":"e_1_2_9_4_1","first-page":"986","article-title":"Gingival crevicular fluid and salivary periostin levels in non\u2010smoker sub\u2010jects with chronic and aggressive periodontitis: Periostin levels inchronic and aggressive periodontitis","volume":"39","author":"Aral C. 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