{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:32:56Z","timestamp":1790735576025,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T00:00:00Z","timestamp":1604793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Head and neck cancer survivors have increased risk of developing second primary tumors compared to overall population. Because second primary represents a major cause of morbidity and mortality in this population, early detection is fundamental.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this 10\u2010year single\u2010institution study, we investigated the following: incidence, clinical\u2010pathological risk factors, and survival of patients with second primary tumor. We included all patients with diagnosis of squamous cell carcinoma of the head and neck seen at the Modena University Hospital from 2008 to 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1,177 patients included, 222 (18.9%) developed second primary tumor; its survival probability at 5\u00a0years was 40.6%. Alcohol consumption (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0055) and index cancer in oropharynx (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0029), supraglottic larynx (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0000), glottic larynx (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0222) were associated with higher risk of second primary. The most common second primary sites were head and neck district and lung (70, 31.5%, and 67, 30.2%, respectively). Head and neck district were more common in oral cavity (18, 43%) and oropharynx index cancer (20, 31%); lung second primary in hypopharynx (4, 40%), supraglottic larynx (17, 43%), and glottic larynx index cancer (23, 35%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Head and neck cancer survivors developing a second primary tumor have dismal prognosis. Tailored surveillance is recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13681","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T03:54:53Z","timestamp":1602647693000},"page":"1412-1420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Second primary tumors in head and neck cancer patients: The importance of a \u201ctailored\u201d surveillance"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8112-2936","authenticated-orcid":false,"given":"Federica","family":"Bertolini","sequence":"first","affiliation":[{"name":"Division of Oncology University Hospital of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1260-2941","authenticated-orcid":false,"given":"Lucia","family":"Trudu","sequence":"additional","affiliation":[{"name":"Division of Oncology University Hospital of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Banchelli","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Schipilliti","sequence":"additional","affiliation":[{"name":"Division of Oncology University Hospital of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Division of Oncology University Hospital of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paola","family":"Alberici","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology\u2010Head and Neck Surgery Hospital \u201cRamazzini\u201d AUSL Modena  Carpi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Depenni","sequence":"additional","affiliation":[{"name":"Division of Oncology University Hospital of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5954-0939","authenticated-orcid":false,"given":"Elisa","family":"D\u2019Angelo","sequence":"additional","affiliation":[{"name":"Radiation Oncology Unit University Hospital of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Mattioli","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery University Hospital of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rubino","sequence":"additional","affiliation":[{"name":"Radiation Oncology Unit University Hospital of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livio","family":"Presutti","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery University Hospital of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2018.44.5.220"},{"key":"e_1_2_8_3_1","volume-title":"AIOCC guidelines: Italian Head and Neck Oncologic Society","year":"2012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.746218"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27634"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.1713"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24119"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0779"},{"key":"e_1_2_8_10_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"DSM 5","year":"2013"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29340"},{"key":"e_1_2_8_12_1","unstructured":"IARC= international agency for research on cancer.https:\/\/gco.iarc.fr\/"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819860808"},{"key":"e_1_2_8_14_1","volume-title":"\u201cInternational rules for multiple primary cancers (ICD\u2010O third Edition)\u201d","author":"International Association of Cancer Registries","year":"2005"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950315)75:6<1343::AID-CNCR2820750617>3.0.CO;2-T"},{"issue":"10","key":"e_1_2_8_16_1","first-page":"134160","article-title":"Metachronous second primary malignancies after head and neck cancer in a Korean Cohort (1993\u20132010)","volume":"28","author":"Jung Y. 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