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The expression of the candidate genes in mouse orofacial development was inquired from FaceBase. Protein\u2013protein interaction (PPI) network was visualized to identify protein functions. Go and KEGG pathway analyses were performed to explore the underlying risk pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 233 eQTL single\u2010nucleotide polymorphisms (SNPs) in 432 candidate genes were identified to be associated with the risk of NSCL\/P. One hundred and eighty\u2010three susceptible genes were expressed in mouse orofacial development according to FaceBase. PPI network analysis highlighted that these genes involved in ubiquitin\u2010mediated proteolysis (\n                      <jats:italic>KCTD7<\/jats:italic>\n                      ,\n                      <jats:italic>ASB1<\/jats:italic>\n                      ,\n                      <jats:italic>UBOX5<\/jats:italic>\n                      ,\n                      <jats:italic>ANAPC4<\/jats:italic>\n                      ) and DNA synthesis (\n                      <jats:italic>XRCC3<\/jats:italic>\n                      ,\n                      <jats:italic>RFC3<\/jats:italic>\n                      ,\n                      <jats:italic>KAT5<\/jats:italic>\n                      ,\n                      <jats:italic>RHNO1<\/jats:italic>\n                      ) were associated with the risk of NSCL\/P. GO and KEGG pathway analyses revealed that the fatty acid metabolism pathway (\n                      <jats:italic>ACADL<\/jats:italic>\n                      ,\n                      <jats:italic>HSD17B12<\/jats:italic>\n                      ,\n                      <jats:italic>ACSL5<\/jats:italic>\n                      ,\n                      <jats:italic>PPT1<\/jats:italic>\n                      ,\n                      <jats:italic>MCAT<\/jats:italic>\n                      ) played an important role in the development of NSCL\/P.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results identified novel susceptibility genes and pathways associated with the development of NSCL\/P.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13699","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T04:34:38Z","timestamp":1604118878000},"page":"1747-1754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Integrating GWAS and eQTL to predict genes and pathways for non\u2010syndromic cleft lip with or without palate"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1320-4083","authenticated-orcid":false,"given":"Jing","family":"Yang","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"},{"name":"Department of Orthodontics Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical 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