{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:50:31Z","timestamp":1783468231805,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertension is a growing clinical problem in pediatric population. Also, the cause of hypertension is usually unknown and it may result from systemic inflammation related to tooth decay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To estimate the potential association in cross\u2010sectional study between tooth decay and hypertension in children and adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Study group\u201465 children diagnosed with primary arterial hypertension; control subjects\u201444 normotensive children. Blood pressure, dental examination, measurement of salivary cortisol, alpha\u2010amylase, secretory IgA, and lysozyme concentrations were performed in all of the children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Hyper\u2010 and normotensive children had similar peripheral blood morphology and serum biochemical parameters, except of uric acid concentration, which was significantly higher in the study group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.047). Salivary evening concentrations of cortisol and alpha\u2010amylase were significantly higher in hypertensive children (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.002 and\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.004, respectively). Although 24\u2010hr systolic blood pressure (SBP), including daytime and nighttime SBP, correlated with \u201cdecay,\u201d \u201cmicroalbuminuria,\u201d \u201cBMI,\u201d and \u201cglomerular filtration rate\u201d (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0&gt;\u00a0.75,\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0&gt;\u00a0.7,\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0&lt;\u00a0.68, and\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0&lt;\u00a0.43, respectively), in multivariate analysis only \u201cdecay\u201d was associated with hypertension both in children and in adolescents (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tooth decay in children\/adolescents might be regarded as a potent trigger factor of hypertension in individuals in whom all other causes of secondary arterial hypertension have been excluded.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13700","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T05:04:36Z","timestamp":1604120676000},"page":"1822-1833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Dental caries\u2010related primary hypertension in children and adolescents: Cross\u2010sectional study"],"prefix":"10.1111","volume":"27","author":[{"given":"Danuta","family":"Ostalska\u2010Nowicka","sequence":"first","affiliation":[{"name":"Department of Pediatric Nephrology and Hypertension Poznan University of Medical Sciences Poznan 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