{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:49:46Z","timestamp":1773982186193,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T00:00:00Z","timestamp":1608422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The imbalanced host response in front of a dysbiotic biofilm is one of the major aspects of severe periodontitis, which also presents a strong familial aggregation related to the susceptibility factors transmission within family members. This study hypothesized that aggressive periodontitis (GAgP) patients and their descendants could present a similar trend of a local inflammatory response that is different from healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifteen GAgP subjects and their children and fifteen healthy subjects and their children were clinically assessed, and the concentration of interferon (IFN)\u2010\u03b3, interleukin (IL)\u201010, IL\u201017, IL\u20101\u03b2, IL\u20104, IL\u20106, IL\u20108, and tumor necrosis factor (TNF)\u2010\u03b1 was evaluated in the gingival fluid using the multiplexed bead immunoassay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Children from the GAgP group presented lower IL\u201010 and IFN\u2010\u03b3 subgingival concentration than Health children, despite no difference in the clinical parameters. GAgP parents showed a lower IFN\u2010\u03b3, IL\u201010, and IL\u20106 than healthy subjects. IL\u201010\/IL\u20101\u03b2 and IFN\u2010\u03b3\/IL\u20104 ratios were reduced in GAgP dyads, suggesting a familial trend in the subgingival cytokine's profile. The cytokines correlated to the clinical data and were predictors of probing depth increase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GAgP parents and their children presented a similar cytokine profile and an imbalance in the subgingival response characterized by decreased IFN\u2010\u03b3\/IL\u20104 and IL10\/IL\u20101\u03b2 ratios.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13738","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T14:45:19Z","timestamp":1606747519000},"page":"202-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The familial trend of the local inflammatory response in periodontal 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