{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:48:29Z","timestamp":1791632909984,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T00:00:00Z","timestamp":1608768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We present a critical review of the papers published in the international scientific literature on malignant transformation of oral lichen planus (OLP). Our aim is to report the most realistic estimate of the proportion of OLP cases with malignant transformation based on the highest quality of evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Following a literature search, we selected 89 papers that were published on this topic until November 2020. We applied to these papers an adaptation of the methodological quality criteria of the QUIPS tool and we ordered all of them according to their methodological quality. The papers that were in the upper quartile of methodological quality (10 papers) were selected and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pooled proportion (expressed as percentage) of malignant transformation of OLP reported in these high methodological quality papers was 2.28% (95% confidence intervals\u00a0=\u00a01.49\u20133.20).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We observe that the proportion of malignancy is higher in research carried out under strict methodological quality criteria. In this critical review, we propose criteria for conducting follow\u2010up studies on OLP to report on malignant transformation under strict quality standards.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13741","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T06:26:29Z","timestamp":1607063189000},"page":"1908-1918","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["An appraisal of highest quality studies reporting malignant transformation of oral lichen planus based on a systematic review"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0791-6639","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Gonz\u00e1lez\u2010Moles","sequence":"first","affiliation":[{"name":"School of Dentistry University of Granada Granada Spain"},{"name":"Biohealth Research Institute (IBS) Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6942-7772","authenticated-orcid":false,"given":"Pablo","family":"Ramos\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Granada Granada Spain"},{"name":"Biohealth Research Institute (IBS) Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2103-0746","authenticated-orcid":false,"given":"Saman","family":"Warnakulasuriya","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Oral &amp; Craniofacial Sciences King's College London London UK"},{"name":"WHO Collaborating Centre for Oral Cancer London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.03.012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2307\/2685469"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.23576"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2012.734407"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2011.04.009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-1-2"},{"issue":"4","key":"e_1_2_9_8_1","first-page":"264","article-title":"Oral lichen planus and malignant transformation: a retrospective follow\u2010up study of clinical and histopathologic data.","volume":"37","author":"Bornstein M","year":"2006","journal-title":"Quintessence International"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01516.x"},{"key":"e_1_2_9_10_1","volume-title":"Systematic Reviews: CRD\u2019s guidance for undertaking reviews in health care","author":"Centre for Reviews and Dissemination group","year":"2009"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12306"},{"key":"e_1_2_9_12_1","article-title":"Association between oral lichen planus and systemic conditions and medications: Case\u2013control study","author":"Dave A.","year":"2020","journal-title":"Oral Diseases"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.02.001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.2013.10"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177729756"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12885"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12480"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.07.012"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13323"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2020.07.002"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-6-200603210-00010"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-4-201302190-00009"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","unstructured":"Higgins J. 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