{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:40:03Z","timestamp":1790646003548,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670961"],"award-info":[{"award-number":["81670961"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Hypoxia is one of the characteristics of microenvironmental changes after orthognathic surgery for fractures. HIF\u20101\u03b1 is a main regulator of the hypoxic response and plays a crucial role in bone formation, remodelling, and homeostasis. Osteoclasts participate in bone absorption and affect osteogenesis, and osteoclasts differentiate in a path from the oxygen\u2010rich bone marrow to oxygen\u2010deficient bone lesions. Thus, we aimed to study the key functions of HIF\u20101\u03b1 in osteoclasts during mandibular healing after osteotomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The function of HIF\u20101\u03b1 in osteoclasts during fracture healing in osteoclast\u2010specific HIF\u20101\u03b1\u2010conditional\u2010knockout mice was investigated in mandibular osteotomy. Primary osteoclasts were used to explore the expression of HIF\u20101\u03b1 and cardiotrophin\u20101 (CT\u20101) at both the mRNA and protein levels. The ability of BMSCs co\u2010cultured with conditioned media from osteoclast\u2010specific HIF\u20101\u03b1\u2010knockout primary osteoclasts was detected using osteoclast\u2010mediated osteogenesis experiments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Hypoxia\u2010inducible factor\u20101\u03b1 increased osteoclastogenesis and bone resorption, and a delay in bone healing was found in osteoclast\u2010specific HIF\u20101\u03b1\u2010conditional\u2010knockout mice compared with normal mice. HIF\u20101\u03b1\u2010knockout primary osteoclasts inhibited bone resorption and CT\u20101 expression, and HIF\u20101\u03b1 enhanced the osteoclast\u2010mediated stimulation of BMSC differentiation by secreting CT\u20101.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hypoxia\u2010inducible factor\u20101\u03b1 can play a key role in the physiology and pathogenesis of bone resorption by promoting osteoclastogenesis during fracture and influencing osteogenesis through CT\u20101 during bone healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13745","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T03:23:32Z","timestamp":1607052212000},"page":"428-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["HIF\u20101\u03b1 regulates osteoclast activation and mediates osteogenesis during mandibular bone repair via CT\u20101"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3671-5852","authenticated-orcid":false,"given":"Yuanye","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School &amp; Hospital of Stomatology Tongji University Shanghai China"},{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School &amp; Hospital of Stomatology Tongji University Shanghai China"},{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Oral and 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