{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:41Z","timestamp":1772160821608,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR072192"],"award-info":[{"award-number":["AR072192"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The project aims were to identify infectious mechanisms responsible for an extreme form of mandibular osteonecrosis and osteomyelitis in West African populations and test the hypothesis that Mycobacterium tuberculosis plays a pivotal role.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>DNA was extracted from mandibular fragments of 9 of 19 patients previously included in a prospective study leading to the mycobacterial hypothesis. Amplified DNAs were used for preparing libraries suitable for next\u2010generation sequencing. For comparison of the whole\u2010genome sequencing data of the 9 patients with DNAs of both microbiota and human tissues, DIAMOND v0.9.26 was used to align sequencing reads to NCBI\u2010nr database and MEGAN 6 for taxonomy binning and identification of Mycobacterium tuberculosis strains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The data show that mandibular bone fragments of all 9 patients not only contain Homo sapiens and Mycobacterium tuberculosis DNAs; they also contain DNAs of Plasmodium ovale wallikeri, Staphylococcus aureus, Staphylococcus hominis, and Prevotella P3\u2010120\/intermedia; as well as large numbers of DNAs from other infectious components.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The data obtained provide direct evidence to support the conclusion that combinations of Mycobacterium tuberculosis, Plasmodium ovale wallikeri, and other oral bacteria are involved in this particular type of mandibular destruction in West African individuals of many ages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13756","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T12:34:55Z","timestamp":1608122095000},"page":"452-468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mycobacterial and Plasmodium ovale\u2010associated destruction of the jaw bones"],"prefix":"10.1111","volume":"28","author":[{"given":"Xianrui","family":"Yang","sequence":"first","affiliation":[{"name":"Harvard School of Dental Medicine  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam Yongxin","family":"Ye","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negin","family":"Katebi","sequence":"additional","affiliation":[{"name":"Harvard School of Dental Medicine  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Volloch","sequence":"additional","affiliation":[{"name":"Harvard School of Dental Medicine  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley M.","family":"Khullar","sequence":"additional","affiliation":[{"name":"Harvard School of Dental Medicine  Boston MA USA"},{"name":"Drammen Spesialist Senter  Drammen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Patel","sequence":"additional","affiliation":[{"name":"Oral Surgery Dept Guy\u2019s &amp; St Thomas NHS  London UK"},{"name":"Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6070-231X","authenticated-orcid":false,"given":"Bjorn R.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Harvard School of Dental Medicine  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,29]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Anatomy: A regional atlas of the human body, Third Edition. 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