{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:40Z","timestamp":1772160820402,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To evaluate the role of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      and other risk factors in recurrent aphthous stomatitis (RAS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with functional dyspepsia responded to questionnaires regarding demographic and clinical data, anxiety and depression, and a specific RAS questionnaire. They underwent upper digestive endoscopy and\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      evaluation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      476 patients were included and of the 372 evaluated for\n                      <jats:italic>H.\u00a0pylori,<\/jats:italic>\n                      65.6% were\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      \u2010positive. RAS was reported by 32.6% (155\/476). In the bivariate analysis of the 372 patients evaluated for gastric\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      status, positive subjects had a lower RAS prevalence (29.9%; 73\/244) than\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      \u2010negative (41.4%; 53\/128) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.026). Smoking (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.005) and older age (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.034) were also associated with a lower prevalence, while female gender (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.032) and lower income (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.046) presented higher RAS prevalence. In the multivariate analysis,\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      infection (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.017), smoking (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.001), and older age (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.013) were protective factors, while lower income (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.030) and anxiety (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.042) were risk factors. In the multivariate analysis of all patients, female gender, lower income, and more schooling years were risk factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      An unexpected lower prevalence of RAS was found in\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      \u2010positive patients. Smoking, sex, age, income, education, and anxiety were associated with RAS.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13765","type":"journal-article","created":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T02:58:10Z","timestamp":1609556290000},"page":"390-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>Helicobacter pylori<\/i>\n                    and other factors in recurrent aphthous stomatitis: A cross\u2010sectional study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7683-5982","authenticated-orcid":false,"given":"Daniel Schebela","family":"Mazzoleni","sequence":"first","affiliation":[{"name":"Graduate Program Sciences in Gastroenterology and Hepatology Universidade Federal do Rio Grande do Sul Porto Alegre 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Mendon\u00e7a","family":"Uchoa","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heitor Ribeiro","family":"Birnfeld","sequence":"additional","affiliation":[{"name":"Hospital Santa Rita de Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza Vitelo","family":"Andrighetto","sequence":"additional","affiliation":[{"name":"Graduate Program Sciences in Gastroenterology and Hepatology Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sacha Allebrandt da Silva","family":"Ries","sequence":"additional","affiliation":[{"name":"School of Medicine Universidade Federal do Rio Grande do Sul Porto Alegre 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