{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:23:56Z","timestamp":1791951836018,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T00:00:00Z","timestamp":1610755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["310797\/2019\u20105"],"award-info":[{"award-number":["310797\/2019\u20105"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically integrate the available data published in the literature on oral pigmented lesions (OPL) associated with syndromes, summarizing the clinical and demographic features of the individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>An electronic search was undertaken in six databases. Eligibility criteria were articles in English, Spanish, and Portuguese describing case reports or case series of OPL associated with syndromes. Data were aggregated and statistically evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      About 108 articles reporting 149 cases of individuals with syndromes were identified. Among the affected individuals, nine syndromes were reported. The mean age at diagnosis was 35.93\u00a0years (0.41 to 83\u00a0years), with a predilection for white (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a085\/85.86%) female (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0102\/68.46%) individuals. As regards the number of lesions, 109 (73.15%) were multiple and 40 (26.85%) were single. Lip represented the anatomical location more affected (122 cases\/38.01%), followed by the buccal mucosa (100 cases\/31.15%). Brownish lesions accounted for 82 (69.49%) cases. The mean time of evolution was 10.52\u00a0years (0.16 to 56\u00a0years). OPL preceding diagnosis of the syndrome was observed in 111 (74.50%) cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although these syndromes are uncommon, dentists should be able to recognize their manifestations, since oral manifestations can represent an important aspect in early diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13769","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T13:54:41Z","timestamp":1609768481000},"page":"531-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Oral pigmented lesions in syndromic individuals: A systematic review"],"prefix":"10.1111","volume":"28","author":[{"given":"Lu\u00edse dos Santos","family":"Ferreira","sequence":"first","affiliation":[{"name":"Diagnostic Center for Oral Diseases School of Dentistry Universidade Federal de Pelotas Pelotas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Barcellos","family":"Calderipe","sequence":"additional","affiliation":[{"name":"Diagnostic Center for Oral Diseases School of Dentistry Universidade Federal de Pelotas Pelotas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julianne Bartz","family":"Maass","sequence":"additional","affiliation":[{"name":"Diagnostic Center for Oral Diseases School of Dentistry Universidade Federal de Pelotas Pelotas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1624-0178","authenticated-orcid":false,"given":"Vinicius Coelho","family":"Carrard","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology School of Dentistry Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-5965","authenticated-orcid":false,"given":"Manoela Domingues","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology School of Dentistry Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Department of Oral Diagnosis Piracicaba Dental School Universidade de Campinas Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2258-8071","authenticated-orcid":false,"given":"Lucas Guimar\u00e3es","family":"Abreu","sequence":"additional","affiliation":[{"name":"Department of Child\u2019s and Adolescent\u2019s Oral Health School of Dentistry Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0993-936X","authenticated-orcid":false,"given":"Lauren Frenzel","family":"Schuch","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School Universidade de Campinas Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6560-9536","authenticated-orcid":false,"given":"Ana Carolina","family":"Uchoa Vasconcelos","sequence":"additional","affiliation":[{"name":"Diagnostic Center for Oral Diseases School of Dentistry Universidade Federal de Pelotas Pelotas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-3400226"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0466"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"144","article-title":"S\u00edndrome de McCune\u2010Albright","volume":"37","author":"Bort G. 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