{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:44Z","timestamp":1772160824353,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The merging of ameloblastoma (AM) with mural unicystic ameloblastoma (UAM\u2010M) was suggested by the 2017 WHO based on similar treatment needs. In an international multicenter study, we investigated the characteristics of their merged product (merged\u2010AM) and raised the possibility of unifying AM and UAM (total\u2010AM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      AM and UAM (luminal\/intraluminal\/mural), separate and combined, were analyzed for demographic\/clinical\/radiological features. ANOVA and chi\u2010square tests were followed by univariate and multivariate analyses, and significance was set at\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The patients\u2019 mean age was 39.6\u00a0\u00b1\u00a020.3\u00a0years in merged\u2010AM (147 AM, 76 UAM\u2010M), 45.1\u00a0\u00b1\u00a019.4\u00a0years in AM (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.009). Merged\u2010AM comprised 51.3% multilocular\/48.7% unilocular tumors, AM comprised 72.5%\/27.5%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Merged\u2010AM was associated with impacted teeth in 30.8%, AM in 18% (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.023). The probability of merged\u2010AM for multilocularity increased by 2.4% per year of age (95%CI 0.6\u20134.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.009). Association with impacted teeth decreased by 7.9% per year of age (95%CI 1.9\u201314.39,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.009). Merged\u2010AM did not differ from total\u2010AM (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Merged\u2010AM partially differed from AM, but differences appeared to diminish in an age\/time\u2010wise manner. Merged\u2010AM and total\u2010AM were nearly indistinguishable. Therefore, AM and UAM may be considered a continuous spectrum of one type of tumor, further necessitating revision of the treatment approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13770","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T08:29:11Z","timestamp":1610008151000},"page":"703-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Conceptual changes in ameloblastoma: Suggested re\u2010classification of a \"veteran\" tumor"],"prefix":"10.1111","volume":"28","author":[{"given":"Ayelet","family":"Zlotogorski\u2010Hurvitz","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging School of Dental Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Department of Oral &amp; Maxillofacial Surgery Rabin Medical Center Petah Tikva 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Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuula","family":"Salo","sequence":"additional","affiliation":[{"name":"Translational Immunology Program Faculty of Medicine University of Helsinki Helsinki Finland"},{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki Helsinki Finland"},{"name":"Medical Research Center Oulu Oulu University Hospital Oulu Finland"},{"name":"Cancer Research and Translational Medicine Research Unit Faculty of Medicine University of Oulu Oulu Finland"},{"name":"Department of Pathology HUSLAB Helsinki University Central Hospital University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0107-4939","authenticated-orcid":false,"given":"Matti","family":"Mauramo","sequence":"additional","affiliation":[{"name":"Department of Pathology HUSLAB Helsinki University Central Hospital University of Helsinki Helsinki Finland"},{"name":"University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lazar","family":"Kats","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging School of Dental Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amos","family":"Buchner","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging School of Dental Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-2333","authenticated-orcid":false,"given":"Marilena","family":"Vered","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging School of Dental Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Institute of Pathology Sheba Medical Center Ramat Gan 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