{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:39:26Z","timestamp":1785231566625,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970949"],"award-info":[{"award-number":["81970949"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371147"],"award-info":[{"award-number":["81371147"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771080"],"award-info":[{"award-number":["81771080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Oral lichen planus (OLP) is a T cell\u2010mediated inflammatory disease with uncertain etiology. Exosomes are cell\u2010derived vesicles containing biological cargo, being associated with the development of multiple inflammatory diseases. The present study aims to investigate the role of T cell\u2010derived exosomes in the pathogenesis of OLP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Exosomal marker CD63 was detected in OLP lesions by immunohistochemistry. Twenty\u2010three cytokines in T cell\u2010derived exosomes were assessed using luminex xMAP\u2010based assay. After co\u2010incubating with exosomes, the apoptosis of keratinocytes and the proliferation of Jurkat cells were assessed via flow cytometry and cell counting kit\u20108 assay, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CD63 was highly expressed in the lymphocyte infiltrated areas of OLP lesions. OLP T cell\u2010derived exosomes contained upregulated interleukin\u20107, \u201010, \u201012, \u201017 and downregulated interleukin\u20101\u03b2, \u20105, and interferon\u2010\u03b3. Both exosomes from OLP patients and controls induced the apoptosis of keratinocytes and altered their morphology. Moreover, healthy control\u2013derived exosomes markedly inhibited the proliferation of Jurkat cells, whereas OLP\u2010derived exosomes exhibited no inhibitory effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OLP T cell\u2010derived exosomes have an aberrant cytokine profile and could trigger the apoptosis of keratinocytes in vitro, which may be involved in the pathogenesis of OLP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13795","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T05:25:10Z","timestamp":1612589110000},"page":"682-690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["T cell\u2010derived exosomes containing cytokines induced keratinocytes apoptosis in oral lichen planus"],"prefix":"10.1111","volume":"28","author":[{"given":"Jing\u2010Ya","family":"Yang","sequence":"first","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Qin","family":"Tan","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Department of Oral Medicine School and Hospital of Stomatology Wuhan University Wuhan 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