{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T21:44:15Z","timestamp":1780350255656,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/16077\u20106"],"award-info":[{"award-number":["2018\/16077\u20106"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/26764\u20108"],"award-info":[{"award-number":["2017\/26764\u20108"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303589\/2019\u20101"],"award-info":[{"award-number":["303589\/2019\u20101"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ 00205.16"],"award-info":[{"award-number":["APQ 00205.16"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Trophoblast cell surface antigen 2 (TROP2) has unclear clinical role in oral squamous cell carcinomas (OSCC). Here, we investigated the association of TROP2 immunoexpression with clinicopathological parameters and survival of OSCC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>Cancer\u2010specific survival (CSS) and disease\u2010free survival (DFS) were assessed in a cohort composed of 266 OSCC. An independent cohort with 88 OSCC samples matched with the normal oral tissue, as well as 17 metastatic lymph nodes, was used for validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariate analysis showed TROP2 as an independent marker of favorable prognosis for both CSS (HR: 0.60, 95% CI: 0.40\u20130.90,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01) and DFS (HR: 0.57, 95% CI: 0.36\u20130.89,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01). Furthermore, TROP2 protein expression was significantly higher in morphologically normal tissues compared to primary tumors (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001) and lymph node metastases (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.001), and it was significantly associated with CSS (HR: 0.26, 95% CI: 0.09\u20130.74,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.008) in the validation cohort. A pooled mRNA analysis performed on the Oncomine\u2122 database confirmed the underexpression in OSCC compared with normal tissues (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.014).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In summary, our results point to a favorable prognostic significance of TROP2 overexpression in a large cohort of oral cancer patients, suggesting it as an attractive clinical marker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13809","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T03:14:55Z","timestamp":1613963695000},"page":"1085-1093","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Trophoblast cell surface antigen 2 expression predicts outcome in oral squamous cell carcinomas"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0906-4153","authenticated-orcid":false,"given":"Mauricio Rocha","family":"Dourado","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School University of Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1697-3662","authenticated-orcid":false,"given":"Renato Assis","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School University of Campinas  Piracicaba Brazil"},{"name":"Hospital for Rehabilitation of Craniofacial Anomalies University of S\u00e3o Paulo (HRAC\/USP)  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3347-4494","authenticated-orcid":false,"given":"L\u00edvia M\u00e1ris Ribeiro","family":"Parana\u00edba","sequence":"additional","affiliation":[{"name":"Department of Pathology and Parasitology Institute of Biomedical Sciences Federal University of Alfenas  Alfenas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-4948","authenticated-orcid":false,"given":"Wilfredo Alejandro","family":"Gonz\u00e1lez\u2010Arriagada","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Diagnosis Faculty of Dentistry Universidad de Valpara\u00edso  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Daniela","family":"da Silva","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research Segal Cancer Center Jewish General Hospital  Montreal QC Canada"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00cdris","family":"Sawazaki\u2010Calone","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Oral Medicine Dental School Western Paran\u00e1 State University  Cascavel Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgard","family":"Graner","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School University of Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuula","family":"Salo","sequence":"additional","affiliation":[{"name":"Cancer and Translational Medicine Research Unit Faculty of Medicine and Medical Research Centre Oulu Oulu University Hospital University of Oulu  Oulu Finland"},{"name":"Department of Pathology Institute of Oral and Maxillofacial Disease Helsinki University Hospital University of Helsinki and HUSLAB  Helsinki 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