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EBV was not detected in any case investigated. The HPV(+) group demonstrated an increase of staining scores for nuclear p16 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.047), cytoplasmic MYC (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002), while a decrease for nuclear MLH1 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.048), suggesting that HPV may upregulate the expression of the first two proteins and down\u2010regulate the latter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings reinforce the hypothesis of the HPV\u2010related oral carcinogenesis involving the expression of p16 and MYC, and MLH1 suppression. Exclusively cytoplasmic stainings for p16, MLH1, and MYC were also associated with more advanced tumors. Finally, in view of the lack of studies correlating the HPV or EBV infection to the expression of oncoproteins, more researches assessing a broader panel of markers and employing different approaches are still necessary in order to understand the role of these viruses as well as the molecular mechanisms involved in the development and progression of oral carcinomas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13814","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T13:22:07Z","timestamp":1614864127000},"page":"1104-1122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of HPV and EBV in OSCC and the expression of p53, p16, E\u2010cadherin, COX\u20102, MYC, and MLH1"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8127-7308","authenticated-orcid":false,"given":"Marcos Antonio Pereira","family":"de 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