{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:08:51Z","timestamp":1777100931224,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to explore the role of long intergenic non\u2010protein coding RNA 460 (LINC00460) in tongue squamous cell carcinoma (TSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 27 TSCC patients to explore LINC00460 expression in clinical TSCC samples. RT\u2010qPCR measured expression of molecules in this research. Loss\u2010of\u2010function assays explored biological function of LINC00460 in TSCC cells. RNA pull\u2010down assay, luciferase reporter assay, and RIP assay investigated mechanism of LINC00460 underlying TSCC cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>TSCC tissues and cell lines both showed high expression of LINC00460. Functionally, LINC00460 downregulation inhibited TSCC cell growth and promoted TSCC cell apoptosis. Additionally, LINC00460 silencing suppressed tumor growth in vivo. Mechanistically, LINC00460 bound with microRNA 320b (miR\u2010320b) in TSCC cells. MiR\u2010320b overexpression suppressed TSCC cell growth and promoted TSCC cell apoptosis. Moreover miR\u2010320b targeted insulin\u2010like growth factor 2 mRNA\u2010binding protein 3 (IGF2BP3) 3\u2032untranslated region in TSCC cells. Furthermore, IGF2BP3 silencing suppressed TSCC cell growth and promoted TSCC cell apoptosis. IGF2BP3 upregulation countervailed effects of silenced LINC00460 on TSCC cells. The LINC00460\/miR\u2010320b\/IGF2BP3 axis was associated with lymph node metastasis of TSCC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our research illustrated that LINC00460 facilitated TSCC progression via the miR\u2010320b\/IGF2BP3 axis, highlighting a potential insight for the treatment of TSCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13828","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T03:32:17Z","timestamp":1614828737000},"page":"1496-1508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["LINC00460 facilitated tongue squamous cell carcinoma progression via the miR\u2010320b\/IGF2BP3 axis"],"prefix":"10.1111","volume":"28","author":[{"given":"Kankui","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Stomatology The Second Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology The Affiliated Huaian No.1 People\u2019s Hospital of Nanjing Medical University  Huaian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiming","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Stomatology The Affiliated Huaian No.1 People\u2019s Hospital of Nanjing Medical University  Huaian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Huaian Maternal and Child Health Hospital  Huaian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5073-5329","authenticated-orcid":false,"given":"Dazhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology The Affiliated Huaian No.1 People\u2019s Hospital of Nanjing Medical University  Huaian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Stomatology The Second Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2019.01.011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a032771"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476\u20104598\u201010\u201038"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577\u2010019\u201000262\u20104"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102094"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.07.081"},{"issue":"3","key":"e_1_2_9_8_1","first-page":"877","article-title":"Oral cavity squamous cell carcinoma\u2013An overview","volume":"13","author":"Kimple A. 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