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Matrix\u2010assisted laser desorption\/ionization time\u2010of\u2010flight mass spectrometry (MALDI\u2010TOF MS) was carried out to detect changes in peptidomic profiles. Then, nano\u2010liquid chromatography\u2010electrospray ionization\u2010tandem mass spectrometry (nano\u2010LC\/ESI\u2010MS\/MS) was performed to identify potential peptide biomarkers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most of the peptides from the patients exhibited a decreasing trend from the time point of pretreatment to that of post\u2010treatment. Cluster analysis and scatter plots using these peptides indicated that salivary peptidome has an acceptable capability of reflecting the status of stage I\/II generalized periodontitis. Seven of these peptides were successfully identified as \u03b1\u20101\u2010antitrypsin, immunoglobulin \u03ba variable 4\u20101, haptoglobin, and immunoglobulin heavy constant \u03b32.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Certain peptides in saliva, serum, and GCF were down\u2010regulated after non\u2010surgical periodontal treatment, demonstrating the application prospects of saliva in monitoring and surveillance of periodontal diseases in both clinical settings and communities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13838","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T02:07:48Z","timestamp":1615342068000},"page":"1640-1651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Peptidomic changes of saliva after non\u2010surgical 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Gene Research School of Life Sciences Peking University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer Elizabeth","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Joint International Research Center of Translational and Clinical Research Peking University Health Science Center and King\u2019s College London  Beijing &amp; London China &amp; United Kingdom"},{"name":"Faculty of Dentistry, Oral and Craniofacial Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Sun","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Key Laboratory of Digital Stomatology Department of Preventive Dentistry National Clinical Research Center for Oral Diseases Peking University School and Hospital of Stomatology  Beijing China"},{"name":"Joint International Research Center of 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