{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:00:53Z","timestamp":1783576853854,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study sought to investigate the effect of miR\u20105191 on proliferation, invasion and metastasis in salivary adenoid cystic carcinoma (SACC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The differential expression level of miR\u20105191 between 5 primary tumor and adjacent non\u2010neoplastic samples, and in two SACC cell lines was detected by quantitative real\u2010time PCR. Cell proliferation, invasion, and migration were performed, followed by luciferase reporter assay and western analysis. The effect of miR\u20105191 on cell proliferation and apoptosis was evaluated by cell growth and apoptosis assay. The function of miR\u20105191 in SACC tumorigenesis and metastasis in vivo was investigated by nude mice experiment. The associations between miR\u20105191\/Notch\u20102 expression and clinicopathological features were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>miR\u20105191 was downregulated in primary tumor tissues and SACC\u2010LM cells. By targeting Notch\u20102, miR\u20105191 expression level affected the migration, invasion, and proliferation of SACC cells. Overexpression of miR\u20105191 inhibited the expression levels of Notch\u20102, followed by the decreased expression of c\u2010Myc, Bcl\u20102, Hes\u20101, Hey\u20101, and Cyclin D1. In vivo, miR\u20105191 overexpression suppressed the SACC tumorigenesis and pulmonary metastasis in mice. In SACC patients, higher expression of miR\u20105191 was related to better prognoses and lower possibility of metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>miR\u20105191 acts as a tumor suppressor in SACC by targeting Notch\u20102.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13841","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T03:47:18Z","timestamp":1615434438000},"page":"1871-1881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["miR\u20105191 acts as a tumor suppressor in salivary adenoid cystic carcinoma by targeting Notch\u20102"],"prefix":"10.1111","volume":"28","author":[{"given":"Zhi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Stomatology Jinling Hospital Jinling Clinical College of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Nanjing Stomatological Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Stomatology Jinling Hospital Jinling Clinical College of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu\u2010Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Faculty of Computer Science University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Stomatology Jinling Hospital Jinling Clinical College of Nanjing Medical University  Nanjing 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