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Thereafter, implants were uncovered and customized abutments were screwed into implants. A high\u2010fat diet and a low\u2010dose injection of streptozotocin were utilized to induce T2DM. Finally, LPS was locally injected in implant sulcus to induce peri\u2010implantitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the present study, T2DM\u2010PI model has been successfully established. Imaging analysis revealed that abundant inflammatory cells infiltrated in the soft tissue in T2DM\u2010PI group with concomitant excessive secretion of inflammatory cytokines. Moreover, higher expression of MMP and increased number of osteoclasts led to collagen disintegration and bone resorption in T2DM\u2010PI group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results describe a novel rat model which stimulate T2DM\u2010PI in vivo, characterized by overwhelming inflammatory response and bone resorption. 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