{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:42:19Z","timestamp":1779338539306,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the clinical and biochemical efficacy of laser therapy as an adjunct to non\u2010surgical treatment in chronic periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was performed through the PubMed, EMBASE, and Cochrane Library for eligible articles published as of May 2, 2020, supplemented by information search in the System for Information on Programme Literature in Europe and a manual literature search. Only randomized controlled trials (RCTs) used to compare the adjunctive use of laser and non\u2010surgical treatment alone with an observation period of at least 6\u00a0months were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixteen RCTs with a total of 525 subjects were included. Meta\u2010analysis suggested that the additional use of laser to scaling and root planing (SRP) showed significant superiority over SRP alone among most of clinical parameters involved. Regarding the GCF, although volume in the laser group was lower at week 4 and 12, no significant difference was found regarding the cytokines level. Subgroup analysis revealed that the combined therapy produced no significant difference in PD, CAL and PI at most time points for studies in respect to smokers. No treatment\u2010related adverse events had been reported in the included studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pooled analysis suggested that laser\u2010assisted non\u2010surgical treatment improved clinical outcome to SRP alone in the management of non\u2010smoking chronic periodontitis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13847","type":"journal-article","created":{"date-parts":[[2021,3,14]],"date-time":"2021-03-14T01:30:16Z","timestamp":1615685416000},"page":"1042-1057","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Clinical and biochemical effect of laser as an adjunct to non\u2010surgical treatment of chronic periodontitis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5706-0125","authenticated-orcid":false,"given":"Yiyang","family":"Jiang","sequence":"first","affiliation":[{"name":"Laboratory of Tissue Regeneration and Immunology and Department of Periodontics Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction School of Stomatology Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of General Dentistry School of Stomatology Wangfujing Division Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[{"name":"Laboratory of Tissue Regeneration and Immunology and Department of Periodontics Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction School of Stomatology Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0597-7438","authenticated-orcid":false,"given":"Jingfei","family":"Fu","sequence":"additional","affiliation":[{"name":"Laboratory of Tissue Regeneration and Immunology and Department of Periodontics Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction School of Stomatology Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yitong","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Tissue Regeneration and Immunology and Department of Periodontics Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction School of Stomatology Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7537-2640","authenticated-orcid":false,"given":"Lijia","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthodontics School of Stomatology Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4998-5547","authenticated-orcid":false,"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Tissue Regeneration and Immunology and Department of Periodontics Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction School of Stomatology Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12080"},{"issue":"3","key":"e_1_2_10_3_1","first-page":"139","article-title":"Laser in periodontal pockets: In vivo and in vitro study","volume":"34","author":"Arcuri C.","year":"2020","journal-title":"Journal of Biological Regulators and Homeostatic Agents"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100195"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12245"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1795-5"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050417"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12137"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-010-0864-z"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13005-016-0116-y"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-014-1685-2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-2526"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2011.3184"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0703-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874210601711010079"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-2047-z"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb01709.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2008.00283.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_189_19"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-019-02875-5"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-019-0062-1"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12726"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2017.02.010"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060292"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12047"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01118.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.2660"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2011.3069"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12104"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12147"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150328"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.5455\/msm.2013.25.196-198"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01560.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-012-1230-0"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13236"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140258"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01259.x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1710-0"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-020-02990-8"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-013-1293-6"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.1.3"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"issue":"2","key":"e_1_2_10_46_1","first-page":"51","article-title":"Laser treatment as an adjunct to debridement of periodontal pockets","volume":"26","author":"Sj\u00f6str\u00f6m L.","year":"2002","journal-title":"Swedish Dental Journal"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2004.03675.x"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2013.3506"},{"issue":"9","key":"e_1_2_10_49_1","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.4103\/njcp.njcp_51_18","article-title":"Clinical and biochemical effects of erbium, chromium: Yttrium, scandium, gallium, garnet laser treatment as a complement to periodontal treatment","volume":"21","author":"Ustun K.","year":"2018","journal-title":"Nigerian Journal of Clinical Practice"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.4103\/jispcd.JISPCD_241_20"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2018.4510"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13107"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.13847","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.13847","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.13847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T19:20:21Z","timestamp":1692991221000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.13847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,3]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/odi.13847"],"URL":"https:\/\/doi.org\/10.1111\/odi.13847","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ODI.13847\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.13847\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.13847\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.13847\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.13847\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.13847\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.13847\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.13847\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.13847\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.13847\/v3\/review1","asserted-by":"object"}]},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,3]]},"assertion":[{"value":"2020-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}