{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:51:33Z","timestamp":1790506293392,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Our study aimed to observe the distribution of putative stem cells in irreversible pulpitis and to investigate the expression of specific molecules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>Extracted third molar teeth were collected and divided into two groups: the normal pulp group and inflamed pulp group. Real\u2010time PCR was applied to detect the expression of several embryonic and dentinogenic genes. The expression of mesenchymal cell markers (STRO\u20101, CD90, and CD146) and stromal cell\u2010derived factor 1\u03b1 (SDF\u20101\u03b1)\/CXC chemokine receptor 4 (CXCR4) proteins was examined by immunohistochemical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The expression levels of most embryonic and dentinogenic genes were not statistically different between the two groups. Immunohistochemical analysis revealed that in inflamed pulp, cells with positive expression for STRO\u20101, CD90, and CD146 mainly resided in two specific niches, both adjacent to inflammatory sites: one in the pulp core and another in the odontoblast layer. SDF\u20101\u03b1\u2010 and CXCR4\u2010positive cells were significantly correlated with STRO\u20101\u2010positive cells. Double immunofluorescence analysis indicated that STRO\u20101\u2010positive cells overlapped with SDF\u20101\u03b1\u2010 and CXCR4\u2010positive cells near the inflammatory site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study gave a direct observation of putative stem cells distributed in irreversible pulpitis and implied a role of SDF\u20101\u03b1\/CXCR4 signaling in stem cell\u2010based therapies for reparative dentinogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13850","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T03:53:50Z","timestamp":1615953230000},"page":"1207-1214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Histochemical localization of putative stem cells in irreversible pulpitis"],"prefix":"10.1111","volume":"28","author":[{"given":"Yan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Stomatology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Stomatology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Taihe Hospital Hubei University of Chinese Medicine  Shiyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1650-4604","authenticated-orcid":false,"given":"Jiarong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2217\/rme.10.30"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1075"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2017.06.011"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40496\u2010018\u20100194\u2010y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12868"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20109969(90)90093\u2010p"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345650440041301"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511405322"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12464"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2018.10.004"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.05.015"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321160"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40161"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102591.2012.02016.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511405386"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102591.2012.02068.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.08.010"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2017.06.003"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.4.696"},{"key":"e_1_2_10_21_1","volume-title":"Dental pulp stem cells","author":"Sibel Y.","year":"2013"},{"issue":"1","key":"e_1_2_10_22_1","first-page":"273","article-title":"Reactionary dentinogenesis","volume":"39","author":"Smith A. 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