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The etiology and pathogenesis of OLP are still unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed the bacterial community structure of buccal mucosa in patients with OLP and normal controls by high\u2010throughput sequencing. Fluorescence in situ hybridization (FISH) was used to detect\n                      <jats:italic>Prevotella melaninogenica<\/jats:italic>\n                      (\n                      <jats:italic>P.\u00a0melaninogenica<\/jats:italic>\n                      ) in 13 OLP samples and 10 controls. The amounts of\n                      <jats:italic>P.\u00a0melaninogenica<\/jats:italic>\n                      in OLP buccal mucosa and the expression of inflammatory cytokines in co\u2010culture of mouse\u2010derived macrophages with\n                      <jats:italic>P.\u00a0melaninogenica<\/jats:italic>\n                      were detected by RT\u2010qPCR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>P.\u00a0melaninogenica<\/jats:italic>\n                      was more abundant in OLP than in healthy controls, and the differences were significant at the level of the phylum, family, genus, and species (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). FISH showed that\n                      <jats:italic>P.\u00a0melaninogenica<\/jats:italic>\n                      can invade the epithelium and even the lamina propria of OLP, while no invasion was found in the normal mucosa.\n                      <jats:italic>Prevotella melaninogenica<\/jats:italic>\n                      can adhere to and invade macrophages and then activate the transcription of IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1 in NF\u2010\u03baB signaling pathway.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Prevotella melaninogenica<\/jats:italic>\n                      may be involved in the pathogenic process of OLP, and its specific mechanism deserves further study.\n                    <\/jats:p>\n                  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