{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:46Z","timestamp":1772160826362,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2019GSF108273"],"award-info":[{"award-number":["2019GSF108273"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2017WS215"],"award-info":[{"award-number":["2017WS215"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2018BH021"],"award-info":[{"award-number":["ZR2018BH021"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Medication\u2010related osteonecrosis of the jaw (MRONJ) is the main adverse side effect of bisphosphonates (BPs), mainly owing to the inhibitory effect of BPs on osteoclastogenesis. CircRNAs were identified to be an important factor in regulating cellular processes. The aim of this study was to explore the effect of mmu_circ_0001066 on BP\u2010inhibited osteoclastogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The expression of MRONJ\u2010related miRNA in RANKL\u2010induced RAW264.7 cells treated with BP was analyzed using qRT\u2010PCR analysis. Bioinformatics techniques were applied to screen potential circRNAs. Tartrate\u2010resistant acid phosphatase (TRAP) staining and bone resorption assays were used to examine the effect of mmu_circ_0001066 on osteoclastogenesis. Bioinformatics analysis, luciferase reporter assays, and Western blotting assays were performed to investigate the underlying mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four MRONJ\u2010related miRNAs were upregulated in BP\u2010treated RAW264.7 cells, and the expression of mmu_circ_0001066 was negatively correlated with those of MRONJ\u2010related miRNAs. Furthermore, the upregulation of mmu_circ_0001066 partially attenuated the inhibitory effect of BP on osteoclastogenesis in RAW264.7 cells. Mechanistically, upregulated miR\u201016 suppressed osteoclastogenesis and miR\u201016 inhibitor increased osteoclastogenesis. Furthermore, we have identified that miR\u201016 is a downstream effector of mmu_circ_0001066.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that mmu_circ_0001066 played an important role in the BP\u2010mediated suppression of osteoclastogenesis, which lays a foundation for identifying mmu_circ_0001066 as a potential biomarker for MRONJ.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13871","type":"journal-article","created":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T00:34:45Z","timestamp":1618014885000},"page":"1591-1602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Upregulation of mmu_circ_0001066 attenuates the inhibitory effect of bisphosphonates on osteoclastogenesis"],"prefix":"10.1111","volume":"28","author":[{"given":"Weidong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The Affiliated Hospital of Qingdao University  Qingdao China"},{"name":"School of Stomatology of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Guo","sequence":"additional","affiliation":[{"name":"The Traditional Chinese Medicine Hospital of Huangdao Distract  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8979-3259","authenticated-orcid":false,"given":"Ling","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The Affiliated Hospital of Qingdao University  Qingdao China"},{"name":"Key Lab of Oral Clinical Medicine The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhao","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao\u2010Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2968-1749","authenticated-orcid":false,"given":"Jingjing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endodontics The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The Affiliated 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